Zhu Jun, Li Xiaohong, Wang Yanping, Mu Dezhi, Dai Li, Zhou Guangxuan, Li Qi, Wang He, Liang Juan
National Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.
J Matern Fetal Neonatal Med. 2012 Sep;25(9):1730-4. doi: 10.3109/14767058.2012.663022. Epub 2012 Mar 12.
To determine the prevalence of pregnancies with neural tube defects (NTDs) in China between 2006 and 2008 and to find a better representative monitoring gestational age for total prevalence of NTDs by comparing the prevalence at or greater than 20, 22 or 28 weeks of gestation (abbreviated as P20, P22 and P28, respectively).
The data were retrieved from the National Birth Defects Monitoring Network in China (the Network). All births were monitored on the prevalence of NTDs during the entire gestation period of 2006-2008.
The P28 only represents 34.6% of anencephaly, 70.8% of spina bifida, 53.3% of encephalocele and 53% of the combination of the three types of NTDs during the entire pregnancy. The P20 represents 75.8%, 94.7%, 86% and 85.4% in the above-mentioned categories, respectively. Of the NTDs diagnosed prenatally before 28 weeks of gestation, 45.3% were terminated electively.
The P28 underrepresented 65.4% of anencephaly, 29.2% of spina bifida, 46.7% of encephalocele and 47% of the combined NTDs. The prevalence of NTDs that occurred at or greater than 20 weeks of gestation was more accurate than that at or greater than 28 weeks of gestation.
确定2006年至2008年中国神经管缺陷（NTDs）妊娠的患病率，并通过比较妊娠20周及以上、22周及以上或28周及以上（分别简称为P20、P22和P28）时的患病率，找到一个能更好代表NTDs总患病率的监测孕周。
数据取自中国国家出生缺陷监测网络（该网络）。对2006 - 2008年整个孕期所有出生的婴儿进行NTDs患病率监测。
P28仅代表整个孕期无脑儿患病率的34.6%、脊柱裂患病率的70.8%、脑膨出患病率的53.3%以及三种类型NTDs合并患病率的53%。P20在上述类别中分别代表75.8%、94.7%、86%和85.4%。在妊娠28周前产前诊断出的NTDs中，45.3%被选择性终止妊娠。
P28未涵盖65.4%的无脑儿、29.2%的脊柱裂、46.7%的脑膨出以及47%的合并NTDs。妊娠20周及以上发生的NTDs患病率比妊娠28周及以上发生的NTDs患病率更准确。
