Winsor E J, Brown B S
CMAJ. 1986 Dec 1;135(11):1269-73.
A survey of the records of all hospitals with obstetric services in Nova Scotia revealed that during 1980-84 there were 122 pregnancies involving a neural tube defect. The mean rate was 2/1000 births. Of the affected fetuses or infants 54% had spina bifida, 35% had anencephaly and 11% had encephalocele. The records showed that in the early part of the period studied at least one prenatal ultrasonographic examination had been performed in 60% of the pregnancies; in 1984 the rate was 74%. When examinations done before 16 weeks' gestation were excluded, the overall detection rates at the first ultrasonographic examination were 100% for anencephaly and 73% for spina bifida and encephalocele; the rates improved toward the end of the study period.
对新斯科舍省所有提供产科服务的医院的记录进行的一项调查显示，在1980年至1984年期间，有122例妊娠涉及神经管缺陷。平均发生率为2/1000活产。在受影响的胎儿或婴儿中，54%患有脊柱裂，35%患有无脑畸形，11%患有脑膨出。记录显示，在所研究期间的早期，60%的妊娠至少进行了一次产前超声检查；1984年这一比例为74%。当排除妊娠16周前进行的检查时，首次超声检查时无脑畸形的总体检出率为100%，脊柱裂和脑膨出的检出率为73%；在研究期结束时，这些检出率有所提高。
