Department of Human Movement Science, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology, Trondheim, Norway.
Climacteric. 2013 Feb;16(1):78-87. doi: 10.3109/13697137.2011.646344. Epub 2012 Feb 18.
Age at menopause may affect women's subsequent morbidity and mortality. In contrast to numerous other health outcomes, little is known about the possible effects of physical activity on age at menopause.
To assess the relationship between leisure-time physical activity and age at menopause.
Premenopausal women participating in a population-based health survey (HUNT 2) conducted in the county of Nord-Trøndelag, Norway reported their physical activity in the period of 1995-1997. Age at menopause was reported during 2006-2008 (HUNT 3). Cox proportional hazards models were used to estimate hazard ratios for menopause and logistic regression to estimate odds ratios for early menopause, with 95% confidence intervals, adjusting for age at menarche, parity, use of oral contraceptives prior to the 6 months preceding participation in HUNT 2, symptoms of depression, smoking status, and education.
Women aged 40-49 years at baseline had lower hazard ratios for menopause when participating in any light leisure-time physical activity compared with no activity (p < 0.05) and similar results were observed in 19-39-year-olds. In 50-59-year-old women, the results varied greatly and did not reach statistical significance.
The effects of leisure-time physical activity on age at menopause may be age-dependent. We found indications of earlier menopause for the least active women aged 19-49 years at baseline.
绝经年龄可能会影响女性随后的发病率和死亡率。与许多其他健康结果不同，人们对体育活动对绝经年龄的可能影响知之甚少。
评估休闲时间体力活动与绝经年龄之间的关系。
参加挪威诺德兰特罗姆郡基于人群的健康调查（HUNT2）的绝经前妇女报告了她们在 1995-1997 年期间的体力活动。绝经年龄是在 2006-2008 年期间报告的（HUNT3）。使用 Cox 比例风险模型估计绝经的风险比，并使用逻辑回归估计早绝经的优势比，置信区间为 95%，调整了初潮年龄、产次、HUNT2 前 6 个月使用口服避孕药、抑郁症状、吸烟状况和教育程度。
基线年龄为 40-49 岁的女性与不活动相比，参加任何轻度休闲时间体力活动的绝经风险比均较低（p<0.05），19-39 岁的女性也观察到类似的结果。在 50-59 岁的女性中，结果差异很大，没有达到统计学意义。
休闲时间体力活动对绝经年龄的影响可能是年龄依赖性的。我们发现，基线年龄为 19-49 岁的最不活跃女性有更早绝经的迹象。
