Shelling Andrew N, Ahmed Nasef Noha
Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1142, New Zealand.
Centre for Cancer Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1142, New Zealand.
Antioxidants (Basel). 2023 Aug 11;12(8):1601. doi: 10.3390/antiox12081601.
Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in young women. Oxidative stress has been suggested as an important factor in the decline of fertility in women and POI. In this review, we discuss the mechanisms of oxidative stress implicated in ovarian ageing and dysfunction in relation to POI, in particular mitochondrial dysfunction, apoptosis and inflammation. Genetic defects, autoimmunity and chemotherapy, are some of the reviewed hallmarks of POI that can lead to increased oxidative stress. Additionally, we highlight lifestyle factors, including diet, low energy availability and BMI, that can increase the risk of POI. The final section of this review discusses dietary factors associated with POI, including consumption of oily fish, mitochondria nutrient therapy, melatonin, dairy and vitamins that can be targeted as potential interventions, especially for at-risk women and in combination with personalised nutrition. Understanding the impact of lifestyle and its implications for POI and oxidative stress holds great promise in reducing the burden of this condition.
卵巢早衰（POI）是一种由于卵巢卵泡池功能障碍或过早耗竭而导致的病症，伴有年轻女性生育能力比正常情况更早丧失。氧化应激被认为是女性生育能力下降和卵巢早衰的一个重要因素。在本综述中，我们讨论了与卵巢早衰相关的卵巢衰老和功能障碍中涉及的氧化应激机制，特别是线粒体功能障碍、细胞凋亡和炎症。遗传缺陷、自身免疫和化疗是一些经审查的卵巢早衰特征，它们可导致氧化应激增加。此外，我们强调了生活方式因素，包括饮食、低能量供应和体重指数，这些因素会增加卵巢早衰的风险。本综述的最后一部分讨论了与卵巢早衰相关的饮食因素，包括食用油性鱼类、线粒体营养疗法、褪黑素、乳制品和维生素，这些可作为潜在干预措施的目标，特别是针对高危女性，并结合个性化营养。了解生活方式对卵巢早衰和氧化应激的影响，对于减轻这种病症的负担具有很大的前景。
