Pharmacokinetics and administration method of gentamicin in a patient on haemodialysis.

作者信息

Hiraki Yoichi, Hiraike Mikako, Nagano Masahisa, Ozono Yukari, Manabe Kenichi, Misumi Nobuhiro, Tsuji Yasuhiro, Kamimura Hidetoshi, Karube Yoshiharu

机构信息

Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto, Japan.

出版信息

Scand J Infect Dis. 2012 Aug;44(8):630-4. doi: 10.3109/00365548.2012.655774. Epub 2012 Feb 19.

We investigated the pharmacokinetics of gentamicin in a haemodialysis patient treated for endocarditis caused by methicillin-resistant Staphylococcus aureus and found that the administration of gentamicin immediately prior to dialysis was a suitable strategy for reaching target maximum drug concentration (Cmax) values and low trough levels.