霉酚酸对白色念珠菌细胞周期的影响。
The effect of mycophenolic acid on the cell cycle of Candida albicans.
作者信息
Quinn C M, Bugeja V C, Gallagher J A, Whittaker P A
机构信息
Biology Department, Maynooth College, Ireland.
出版信息
Mycopathologia. 1990 Sep;111(3):165-8. doi: 10.1007/BF02282799.
PMID:2233985
Abstract
Mycophenolic acid inhibited the growth of Candida albicans. Cultures exposed to a concentration of 8.4 micrograms ml-1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis. The results are discussed in relation to the possible mode of action of mycophenolic acid.
摘要
霉酚酸抑制白色念珠菌的生长。发现暴露于浓度为8.4微克/毫升霉酚酸的培养物表现出细胞周期停滞，带有两个或更多芽体。核染色显示这些芽体有细胞核，这意味着胞质分裂可能存在缺陷。结合霉酚酸可能的作用模式对结果进行了讨论。
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