Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Chin Med J (Engl). 2011 Nov;124(21):3556-9.
The prevalence of chronic pancreatitis has increased during recent years in Asia-Pacific areas as well as in China. The etiologies vary in different regions and periods. This study aimed to investigate the changing etiologies of chronic pancreatitis within 20 years at Peking Union Medical College Hospital in China.
Retrospective analysis of the etiologies of 636 cases of chronic pancreatitis at Peking Union Medical College Hospital from 1990 to 2010 was performed. Patients were divided into two groups according to two time periods (1990 - 2000 and 2001 - 2010). Statistical analysis was performed using the chi-square test.
The morbidity rate of chronic pancreatitis in China has recently increased. The main etiology changed from biliary diseases in the 1990s (decreased from 36.8% to 28.1%) to alcohol abuse after the year 2000 (increased from 26.5% to 36.8%). The main etiology of biliary diseases is stones in the cholecyst or bile duct, and the percentage of cholecystitis cases has increased. Autoimmune disease, including autoimmune pancreatitis, has increased quickly and currently accounts for 7.3% of cases because a greater number of autoimmune pancreatitis cases are being diagnosed. Approximately 9.5% of chronic pancreatitis cases are caused by multiple factors such as alcohol abuse and bile duct stones. Other factors include cholecystectomy and acute pancreatitis.
The main etiology of chronic pancreatitis has changed from biliary disease to alcohol abuse in recent years. Autoimmune factors have also obviously increased.
近年来，亚太地区乃至中国的慢性胰腺炎患病率都有所上升。不同地区和时期的病因也有所不同。本研究旨在探讨北京协和医院 20 年来慢性胰腺炎病因的变化。
回顾性分析 1990 年至 2010 年北京协和医院 636 例慢性胰腺炎患者的病因。根据两个时期（1990-2000 年和 2001-2010 年）将患者分为两组。采用卡方检验进行统计学分析。
中国慢性胰腺炎的发病率最近有所上升。主要病因由 90 年代的胆道疾病（从 36.8%降至 28.1%）变为 2000 年后的酒精滥用（从 26.5%升至 36.8%）。胆道疾病的主要病因是胆囊或胆管结石，胆囊炎的比例有所增加。包括自身免疫性胰腺炎在内的自身免疫性疾病迅速增加，目前占病例的 7.3%，因为更多的自身免疫性胰腺炎病例被诊断出来。约 9.5%的慢性胰腺炎病例由酒精滥用和胆管结石等多种因素引起。其他因素包括胆囊切除术和急性胰腺炎。
近年来，慢性胰腺炎的主要病因已从胆道疾病转变为酒精滥用，自身免疫因素也明显增加。
