Department of Urology, First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, China.
Chin Med J (Engl). 2011 Nov;124(22):3810-5.
To review the effect of stem cells in erectile dysfunction as well as their application to the therapy of erectile dysfunction.
The data used in the present article were mainly from PubMed with relevant English articles published from 1974 to 2011. The search terms were "stem cells" and "erectile dysfunction".
Articles regarding the role of stem cells in erectile dysfunction and their application to the therapy of erectile dysfunction were selected.
Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Meanwhile, in preclinical experiments, therapeutic gene-modified stem cells have been approved to offer a novel strategy for cell therapy and gene therapy of erectile dysfunction.
The transplantation of stem cells has the potential to provide cell types capable of restoring normal function after injury or degradation in erectile dysfunction. However, a series of problems, such as the safety of stem cells transplantation, their application in cell therapy and gene therapy of erectile dysfunction need further investigation.
探讨干细胞在勃起功能障碍中的作用及其在勃起功能障碍治疗中的应用。
本文资料主要来源于 PubMed，检索词为“stem cells”和“erectile dysfunction”，检索时间为 1974 年至 2011 年，收集关于干细胞在勃起功能障碍中的作用及其在勃起功能障碍治疗中的应用的相关英文文献。
选择关于干细胞在勃起功能障碍中的作用及其在勃起功能障碍治疗中的应用的文章。
干细胞具有自我更新和分化为多种细胞类型的能力，为再生医学带来了很大的希望。同时，在临床前实验中，经过基因修饰的治疗性干细胞已被批准为勃起功能障碍的细胞治疗和基因治疗提供新策略。
干细胞移植有可能为勃起功能障碍中的损伤或退化提供能够恢复正常功能的细胞类型。然而，干细胞移植的安全性、其在勃起功能障碍的细胞治疗和基因治疗中的应用等一系列问题仍需进一步研究。
