髓样细胞中的抗原加工和呈递机制。
Antigen Processing and Presentation Mechanisms in Myeloid Cells.
机构信息
Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520.
出版信息
Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0008-2015.
Abstract
Unlike B cells, CD8-positive and CD4-positive T cells of the adaptive immune system do not recognize intact foreign proteins but instead recognize polypeptide fragments of potential antigens. These antigenic peptides are expressed on the surface of antigen presenting cells bound to MHC class I and MHC class II proteins. Here, we review the basics of antigen acquisition by antigen presenting cells, antigen proteolysis into polypeptide fragments, antigenic peptide binding to MHC proteins, and surface display of both MHC class I-peptide and MHC class II-peptide complexes.
摘要
与 B 细胞不同，适应性免疫系统的 CD8 阳性和 CD4 阳性 T 细胞不识别完整的外源蛋白，而是识别潜在抗原的多肽片段。这些抗原肽与 MHC Ⅰ类和 MHC Ⅱ类蛋白结合表达在抗原呈递细胞的表面。在此，我们回顾抗原呈递细胞摄取抗原、抗原蛋白水解成多肽片段、抗原肽与 MHC 蛋白结合以及 MHCⅠ类-肽和 MHCⅡ类-肽复合物表面展示的基础知识。
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2
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Nat Rev Immunol. 2015 Apr;15(4):203-16. doi: 10.1038/nri3818. Epub 2015 Feb 27.
3
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Biochim Biophys Acta. 2015 Apr;1853(4):775-80. doi: 10.1016/j.bbamcr.2014.09.019. Epub 2014 Sep 28.
4
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5
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