Department of Cardiology, the Second Affiliated Hospital, Nantong University, Nantong, Jiangsu 226601, China.
Chin Med J (Engl). 2012 Jan;125(2):378-84.
Poor stem cell survival is one of the obstacles for cell regeneration therapy post myocardial infarction (MI) and responsible for unsatisfactory therapeutic effectiveness. Various approaches to improve the status of these cells and increase cell survival have become research foci. The following article is a mini-review on the utilization of cell preconditioning for stem cell survival.
The data used in this review were mainly from the articles in Medline and PubMed published from 1990 to 2010. The search terms included "preconditioning, stem cell and myocardial infarction".
Original articles and critical reviews selected were relevant to the review's theme.
The harsh ischemic and inflammatory microenvironment in the infarcted myocardium offers a significant challenge to the transplanted donor stem cells. Survival of stem cells following transplantation is affected by many factors, such as limited blood supply, nutritional deficiency, hypoxia, oxidative stress, and inflammation. Preconditioning methods have potent cytoprotective effects, which enables cells to maintain a "standby state" through programmed initiation of cell survival pathways.
The findings suggest that cell preconditioning can be used as an effective anti-apoptotic strategy and enable cells to withstand and survive the harsh environment after transplantation.
细胞再生治疗心肌梗死后（MI）， 干细胞存活率低是其中的障碍之一， 这也是导致治疗效果不理想的原因。 各种提高细胞状态和增加细胞存活率的方法已成为研究焦点。 本文是一篇关于细胞预处理提高干细胞存活率的综述。
本综述数据主要来源于 1990 年至 2010 年 Medline 和 PubMed 发表的文章。 检索词包括“预处理、 干细胞和心肌梗死”。
选择与综述主题相关的原始文章和评论。
在梗死的心肌中， 恶劣的缺血和炎症微环境给移植的供体干细胞带来了巨大的挑战。 移植后干细胞的存活受到许多因素的影响， 如血供有限、 营养缺乏、 缺氧、 氧化应激和炎症。 预处理方法具有强大的细胞保护作用， 通过程序化启动细胞存活途径使细胞保持“待命状态”。
研究结果表明， 细胞预处理可用作有效的抗细胞凋亡策略， 使细胞在移植后能够耐受和适应恶劣的环境。
