Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), Girona, Spain.
Breast. 2012 Oct;21(5):646-51. doi: 10.1016/j.breast.2012.01.014. Epub 2012 Feb 14.
The aim of this study was to describe breast ductal carcinoma in situ (DCIS) incidence trends in women in the Girona province during a period of 25 years. The influence of age, use of mammography and implementation of the breast cancer screening programs was explored. Incidence of subsequent invasive breast cancers (IBC) and DCIS treatment was also considered.
Cases diagnosed with primary pure DCIS (n = 416) during 1983-2007 were extracted from the population-based Girona Cancer Registry. The estimated annual percent change was estimated using joinpoint analysis.
DCIS incidence showed a sharp rise until 1997, followed by a less marked upward trend. Among women aged 50-69 the increase was particularly important between 1992 and in 1996, reflecting the spread in mammography use.
The upward trend of DCIS was mainly related to an increase in mammography use either opportunistic or as a result of screening implementation.
本研究旨在描述 25 年间在西班牙赫罗纳省女性中乳腺导管原位癌（DCIS）的发病趋势。并探讨了年龄、乳腺 X 线摄影术的使用以及乳腺癌筛查计划的实施对其的影响。还考虑了后续浸润性乳腺癌（IBC）和 DCIS 治疗的情况。
从基于人群的赫罗纳癌症登记处中提取了 1983 年至 2007 年间诊断为原发性单纯 DCIS（n=416）的病例。使用 joinpoint 分析估计了估计的年度百分比变化。
DCIS 的发病率直到 1997 年急剧上升，之后呈上升趋势。在 50-69 岁的女性中，1992 年至 1996 年间的增长尤为明显，这反映了乳腺 X 线摄影术使用率的增加。
DCIS 的上升趋势主要与乳腺 X 线摄影术的使用增加有关，这种增加既可以是机会性的，也可以是筛查实施的结果。
