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脊柱关节炎患者指(趾)炎的患病率和临床特征:275 例患者的描述性分析。

Prevalence and clinical characteristics of dactylitis in spondylarthritis: a descriptive analysis of 275 patients.

机构信息

Paris Descartes University, Medicine Faculty, APHP, Rheumatology B Department, Cochin Hospital, Paris, France.

出版信息

Clin Exp Rheumatol. 2012 Mar-Apr;30(2):191-6. Epub 2012 Apr 13.

Abstract

OBJECTIVES

Dactylitis is a common but little studied feature of spondylarthritis (SpA). Our objective was to assess the prevalence of dactylitis among a cohort of patients with spondylarthritis in a tertiary care centre and to describe the clinical characteristics of dactylitis.

METHODS

This was a prospective single centre observational study carried out in 2010. The patients included had been diagnosed as having definite SpA based on Amo's criteria. Each patient was interviewed by a physician. The data collected included prevalence of dactylitis and its clinical characteristics, effectiveness of the different treatments, and association with severe manifestations of SpA, and analysed by descriptive analysis.

RESULTS

275 consecutive SpA patients were assessed: mean age 43.2±13.5 years, mean disease duration 14.0±11.8 years, 169 (61.4%) were men. In all, 59 patients (21.5%) suffered from SpA-associated dactylitis. The localisation of dactylitis was toes in 46 patients (78.0%) and/or fingers in 25 patients (42.4%). The most frequent localisations were the second toe and the second finger. Dactylitis was the first symptom of SpA in 14 patients (5.1%), and 28.8% (n=17) of dactylitis appeared within the first 5 years of disease. Dactylitis was present in 35.1% (n=13) of patients with undifferenciated SpA and in 30.6% (n=15) of patients with psoriatic arthritis. It was significantly associated with history of peripheral arthritis or heel pain. In our population, there was no correlation between dactylitis and HLA B27 status or sex and it was not a marker of severity of disease.

CONCLUSIONS

Dactylitis is a frequent manifestation in SpA (21.5%) particularly in peripheral disease and it may be the first manifestation of the disease with localisation being more frequent in the toes.

摘要

目的

指(趾)炎是脊柱关节炎(SpA)的一种常见但研究较少的特征。我们的目的是评估三级保健中心 SpA 患者队列中指(趾)炎的患病率,并描述指(趾)炎的临床特征。

方法

这是一项于 2010 年进行的前瞻性单中心观察性研究。纳入的患者已根据 Amo 标准被诊断为明确的 SpA。每位患者均由一名医生进行访谈。收集的数据包括指(趾)炎的患病率及其临床特征、不同治疗方法的疗效以及与 SpA 严重表现的关联,并通过描述性分析进行分析。

结果

共评估了 275 例连续的 SpA 患者:平均年龄 43.2±13.5 岁,平均病程 14.0±11.8 年,169 例(61.4%)为男性。共有 59 例(21.5%)患者患有 SpA 相关的指(趾)炎。指(趾)炎的部位为脚趾 46 例(78.0%)和/或手指 25 例(42.4%)。最常见的部位是第二脚趾和第二手指。14 例(5.1%)患者的指(趾)炎是 SpA 的首发症状,28.8%(n=17)的指(趾)炎出现在疾病的前 5 年内。未分化 SpA 患者中 35.1%(n=13)和银屑病关节炎患者中 30.6%(n=15)存在指(趾)炎。指(趾)炎与外周关节炎或足跟痛病史显著相关。在我们的人群中,指(趾)炎与 HLA B27 状态或性别之间没有相关性,也不是疾病严重程度的标志。

结论

指(趾)炎是 SpA 的一种常见表现(21.5%),特别是在周围疾病中,它可能是疾病的首发表现,病变部位更常见于脚趾。

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