调强放疗和图像引导放疗以避免下颌骨受到过度辐射的效果。
Effectiveness of intensity-modulated and image-guided radiotherapy to spare the mandible from excessive radiation.
机构信息
Department of Radiation Oncology, University of Arizona, Tucson, AZ, United States.
出版信息
Oral Oncol. 2012 Jul;48(7):653-7. doi: 10.1016/j.oraloncology.2012.01.016. Epub 2012 Feb 16.
We would like to assess the effectiveness of intensity-modulated radiotherapy (IMRT) or image-guided radiotherapy (IGRT) to decrease the risk of osteoradionecrosis in locally advanced head and neck cancer. We conducted a retrospective study of 83 patients with head and neck cancer undergoing concurrent definitive chemoradiation, post-operative radiotherapy or chemoradiation, or radiotherapy alone with IMRT or IGRT. Mean mandibular dose was, respectively, 43.6Gy and 43.8Gy for the IMRT and IGRT technique. At a median follow-up of 28 months (5-55 months), only one patient developed osteoradionecrosis requiring hyperbaric oxygen. Sharp dose falloff associated with IMRT and IGRT decreased excessive radiation of the mandible and may reduce the risks of osteoradionecrosis.
我们希望评估调强放疗（IMRT）或图像引导放疗（IGRT）的有效性，以降低局部晚期头颈部癌症发生放射性骨坏死的风险。我们对 83 例接受同期根治性放化疗、术后放化疗或单纯放疗的头颈部癌症患者进行了回顾性研究，这些患者分别采用了 IMRT 或 IGRT 技术。IMRT 和 IGRT 技术的平均下颌剂量分别为 43.6Gy 和 43.8Gy。中位随访 28 个月（5-55 个月），仅 1 例患者发生放射性骨坏死，需要高压氧治疗。IMRT 和 IGRT 带来的陡峭剂量下降可减少下颌骨的过度照射，从而降低放射性骨坏死的风险。
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