Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.
Carbohydr Res. 2012 Apr 1;351:64-7. doi: 10.1016/j.carres.2012.01.014. Epub 2012 Jan 28.
Eight norlignan glucosides, including two novel skeleton-rearranged compounds, sinenside A (1) and B (2), and six known compounds, crassifoside D (3), capituloside (4), a mixture of (1S,2R)-1-O-methylnyasicoside (5), (1R,2R)-1-O-methylisonyasicoside (6), and a mixture of (1S,2R)-1-O-methylcurculigine (7) and (1R,2R)-1-O-methylisocurculigine (8), were isolated from the rhizomes of Curculigo sinensis. Compounds 3-8 were isolated for the first time from this plant. Structures of the isolated compounds were established by spectroscopic analysis, including UV, IR, HRESI-MS, and 1D/2D NMR, and hydrolysis experiments. The free radical scavenging activity of the isolated compounds was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. All the isolated compounds showed strong radical scavenging activities.
从仙茅根茎中分离得到 8 个橄榄烷型葡萄糖苷，包括 2 个新骨架重排化合物，仙茅苷 A（1）和 B（2），以及 6 个已知化合物，粗穗仙茅苷 D（3）、头花千金藤苷（4）、（1S,2R）-1-O-甲基尼卡考苷（5）、（1R,2R）-1-O-甲基异尼卡考苷（6）和（1S,2R）-1-O-甲基光千金藤碱（7）和（1R,2R）-1-O-甲基异光千金藤碱（8）。化合物 3-8 为首次从该植物中分离得到。通过光谱分析，包括 UV、IR、HRESI-MS 和 1D/2D NMR 以及水解实验，确定了分离得到的化合物的结构。通过 1,1-二苯基-2-苦基肼（DPPH）测定法评估了分离得到的化合物的自由基清除活性。所有分离得到的化合物均表现出较强的自由基清除活性。
