脑岛-屏状核区域与精神分裂症妄想
The insula-claustrum region and delusions in schizophrenia.
机构信息
Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine,600 North Wolfe Street, Baltimore, MD 21287, USA.
出版信息
Schizophr Res. 2011 Dec;133(1-3):77-81. doi: 10.1016/j.schres.2011.08.004. Epub 2011 Aug 27.
OBJECTIVE
We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia.
METHOD
MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions.
RESULTS
The analysis revealed significant inverse correlations between ratings of the severity of delusions and volumes of the left claustrum and right insula. Significant correlations were not observed between cerebral GM volume and ratings of hallucinations.
CONCLUSION
The insula/claustrum region may be critical to the experience of delusions and more careful scrutiny of the claustrum in relation to schizophrenia appears warranted.
目的
我们研究了成人精神分裂症患者大脑灰质（GM）体积与妄想和幻觉严重程度之间的关系。
方法
对 43 名精神分裂症患者进行 MRI 扫描。计算 GM 体积与幻觉和妄想严重程度的临床医生评分之间的相关性。
结果
分析显示，妄想严重程度评分与左侧屏状核和右侧脑岛的 GM 体积呈显著负相关。GM 体积与幻觉评分之间未观察到显著相关性。
结论
脑岛/屏状核区域可能对妄想的体验至关重要，因此需要更仔细地研究屏状核与精神分裂症的关系。
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