Department of Child Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.
Sleep Med. 2012 Apr;13(4):429-32. doi: 10.1016/j.sleep.2011.12.009. Epub 2012 Feb 15.
We conducted a retrospective chart review of children with restless legs syndrome (RLS) to evaluate the efficacy of oral iron treatment, which was administered open-label during the course of clinical care. In addition, we provided detailed clinical information about RLS in this pediatric cohort.
The study included 30 consecutive Japanese children with RLS who visited the Pediatric Sleep Clinic at Osaka University Hospital, and consisted of 17 boys and 13 girls, aged 2-14 years (mean ± SD, 6.5 ± 2.8). All-night polysomnography was performed in 18 patients and serum ferritin levels were measured in all the patients. After the diagnosis of RLS, iron was administered at doses between 1.6 and 7.8 mg/kg/day (3.2 ± 1.3). Serum ferritin was re-evaluated 3-6 months after iron treatment, or when RLS symptoms had disappeared.
The patient age at onset of RLS symptoms ranged from six months to 13 years (4.3 ± 3.6). A positive family history was recognized in 19 children (63.3%). Serum ferritin levels before therapy were 9-62 ng/ml (26.6 ± 12.8) and oral iron supplementation was reported to be highly effective in 17 children, effective in 10, and ineffective in three. The serum ferritin level at follow-up was 23-182 ng/ml (83.5 ± 49.8). The onset of treatment effect was within approximately three months.
Iron treatment could be effective in Japanese pediatric RLS.
我们对患有不宁腿综合征（RLS）的儿童进行了回顾性病历审查，以评估口服铁剂治疗的疗效，该治疗在临床护理过程中以开放标签的方式进行。此外，我们还为这一儿科队列提供了有关 RLS 的详细临床信息。
该研究纳入了 30 名连续就诊于大阪大学医院儿科睡眠诊所的日本 RLS 儿童患者，包括 17 名男孩和 13 名女孩，年龄 2-14 岁（均值 ± 标准差，6.5 ± 2.8）。18 名患者进行了整夜多导睡眠图检查，所有患者均测量了血清铁蛋白水平。在诊断为 RLS 后，给予铁剂治疗，剂量为 1.6-7.8mg/kg/天（3.2 ± 1.3）。在铁治疗后 3-6 个月或 RLS 症状消失时，重新评估血清铁蛋白水平。
RLS 症状发作的患者年龄从 6 个月至 13 岁不等（4.3 ± 3.6）。19 名儿童（63.3%）有阳性家族史。治疗前血清铁蛋白水平为 9-62ng/ml（26.6 ± 12.8），17 名儿童报告口服铁补充剂非常有效，10 名有效，3 名无效。随访时血清铁蛋白水平为 23-182ng/ml（83.5 ± 49.8）。治疗效果的出现时间约为 3 个月内。
铁治疗可能对日本儿科 RLS 有效。
