Suppr超能文献

血清铁蛋白水平改善能否改善儿科患者群体中不安腿综合征的症状?

Does Improvement of Low Serum Ferritin Improve Symptoms of Restless Legs Syndrome in a Cohort of Pediatric Patients?

机构信息

Children's Minnesota Sleep Center, Children's Minnesota, St. Paul, Minnesota.

Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, Minnesota.

出版信息

J Clin Sleep Med. 2019 Aug 15;15(8):1149-1154. doi: 10.5664/jcsm.7810.

Abstract

STUDY OBJECTIVES

To determine whether an oral iron supplement improves restless leg/restless sleep symptoms in a pediatric population.

METHODS

In a cohort study, 47 patients (age 5-18 years) exhibiting restless legs/restless sleep symptoms and low serum ferritin levels (< 50 ng/mL) were given a daily oral iron supplement (ferrous sulfate + vitamin C) and re-evaluated 8 weeks later. A diagnosis of definite Restless Legs Syndrome (RLS) was determined based on criteria established by the International RLS Study Group. Using Wilcoxon signed-rank tests and Spearman rho, the change and association between the measures of Pediatric Restless Legs Syndrome Severity Scale and serum ferritin levels were also examined.

RESULTS

Overall, the median change and distribution of ferritin was statistically significantly different after 8 weeks of treatment (40.0 versus 23.0 ng/mL, P < .0001). Median RLS score was also statistically significantly lower from baseline to follow-up (4.0 versus 6.0, P = .0283). Sixteen patients met criteria for definite RLS; however, the change in RLS score was not determined to be significant in our population (9.5 versus 7.0, P = .0558), despite significant change in ferritin (25.0 versus 42.5 ng/mL, P < .0001). In addition, no correlation was observed between change in RLS score and ferritin level (rho = -.39, P = .1362).

CONCLUSIONS

In preliminary findings, we found a modest, yet nonsignificant improvement in children exhibiting restless sleep and RLS symptomatology, despite significant improvement in ferritin levels. Though not statistically significant, the findings can lend to the suggested benefit of iron supplementation in patients with RLS; however, clinical judgment and further research is necessary.

CITATION

Rosen GM, Morrissette S, Larson A, Stading P, Barnes TL. Does improvement of low serum ferritin improve symptoms of restless legs syndrome in a cohort of pediatric patients? J Clin Sleep Med. 2019;15(8):1149-1154.

摘要

研究目的

确定口服铁补充剂是否能改善儿科人群的不安腿/不安睡眠症状。

方法

在一项队列研究中,47 名(5-18 岁)表现出不安腿/不安睡眠症状和低血清铁蛋白水平(<50ng/ml)的患者每天口服铁补充剂(硫酸亚铁+维生素 C),并在 8 周后重新评估。根据国际不安腿综合征研究组制定的标准,确定明确的不安腿综合征(RLS)诊断。使用 Wilcoxon 符号秩检验和 Spearman rho,还检查了儿科不安腿综合征严重程度量表和血清铁蛋白水平的测量值之间的变化和关联。

结果

总体而言,治疗 8 周后铁蛋白的中位数变化和分布在统计学上有显著差异(40.0 与 23.0ng/ml,P<0.0001)。从基线到随访时,RLS 评分中位数也有统计学显著降低(4.0 与 6.0,P=0.0283)。16 名患者符合明确 RLS 的标准;然而,我们的人群中 RLS 评分的变化没有统计学意义(9.5 与 7.0,P=0.0558),尽管铁蛋白有显著变化(25.0 与 42.5ng/ml,P<0.0001)。此外,RLS 评分变化与铁蛋白水平之间未观察到相关性(rho=-0.39,P=0.1362)。

结论

在初步研究结果中,我们发现尽管血清铁蛋白水平显著改善,但表现出不安睡眠和 RLS 症状的儿童有适度但无统计学意义的改善。尽管没有统计学意义,但这些发现可以证明铁补充对 RLS 患者的益处;然而,需要临床判断和进一步的研究。

引文

Rosen GM,Morrissette S,Larson A,Stading P,Barnes TL。低血清铁蛋白水平改善是否能改善儿科患者不安腿综合征的症状?J 临床睡眠医学。2019;15(8):1149-1154。

相似文献

4
Outcomes of long-term iron supplementation in pediatric restless legs syndrome/periodic limb movement disorder (RLS/PLMD).
Sleep Med. 2017 Apr;32:213-219. doi: 10.1016/j.sleep.2016.01.008. Epub 2016 Feb 12.
5
Evaluation of oral iron treatment in pediatric restless legs syndrome (RLS).
Sleep Med. 2012 Apr;13(4):429-32. doi: 10.1016/j.sleep.2011.12.009. Epub 2012 Feb 15.
7
Treatment of pediatric restless legs syndrome.
Clin Pediatr (Phila). 2014 Apr;53(4):331-6. doi: 10.1177/0009922813507997. Epub 2013 Nov 6.
8
Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose.
Sleep Med. 2013 Nov;14(11):1100-4. doi: 10.1016/j.sleep.2013.06.006. Epub 2013 Aug 28.
9
Early childhood-onset restless legs syndrome: symptoms and effect of oral iron treatment.
Acta Paediatr. 2013 May;102(5):e221-6. doi: 10.1111/apa.12173. Epub 2013 Mar 6.

引用本文的文献

1
Restless Legs and Iron Deficiency: Unraveling the Hidden Link and Unlocking Relief.
Cureus. 2025 Apr 17;17(4):e82413. doi: 10.7759/cureus.82413. eCollection 2025 Apr.
5
Intravenous Iron-Carbohydrate Nanoparticles and Their Similars. What Do We Choose?
Maedica (Bucur). 2022 Jun;17(2):436-448. doi: 10.26574/maedica.2022.17.2.436.
6
Intravenous iron therapy in the pediatric sleep clinic: a single institution experience.
J Clin Sleep Med. 2022 Nov 1;18(11):2545-2551. doi: 10.5664/jcsm.10152.
7
Restless Sleep Disorder (RSD): a New Sleep Disorder in Children. A Rapid Review.
Curr Neurol Neurosci Rep. 2022 Jul;22(7):395-404. doi: 10.1007/s11910-022-01200-y. Epub 2022 Jun 14.
8
Management of sleep disorders among children and adolescents with neurodevelopmental disorders: A practical guide for clinicians.
World J Clin Pediatr. 2022 Mar 15;11(3):239-252. doi: 10.5409/wjcp.v11.i3.239. eCollection 2022 May 9.
9
Rethinking bedtime resistance in children with autism: is restless legs syndrome to blame?
J Clin Sleep Med. 2020 Dec 15;16(12):2029-2035. doi: 10.5664/jcsm.8756.
10
Tools for the Assessment of Pediatric Restless Legs Syndrome.
Front Psychiatry. 2020 May 5;11:356. doi: 10.3389/fpsyt.2020.00356. eCollection 2020.

本文引用的文献

2
Outcomes of long-term iron supplementation in pediatric restless legs syndrome/periodic limb movement disorder (RLS/PLMD).
Sleep Med. 2017 Apr;32:213-219. doi: 10.1016/j.sleep.2016.01.008. Epub 2016 Feb 12.
3
Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women.
Blood. 2015 Oct 22;126(17):1981-9. doi: 10.1182/blood-2015-05-642223. Epub 2015 Aug 19.
5
Diagnosis and management of iron deficiency anemia.
Hematol Oncol Clin North Am. 2014 Aug;28(4):729-45, vi-vii. doi: 10.1016/j.hoc.2014.04.007. Epub 2014 Jun 2.
6
Treatment of pediatric restless legs syndrome.
Clin Pediatr (Phila). 2014 Apr;53(4):331-6. doi: 10.1177/0009922813507997. Epub 2013 Nov 6.
7
Iron's role in paediatric restless legs syndrome - a review.
Paediatr Child Health. 2012 Apr;17(4):193-7. doi: 10.1093/pch/17.4.193.
8
Diurnal rhythm rather than dietary iron mediates daily hepcidin variations.
Clin Chem. 2013 Mar;59(3):527-35. doi: 10.1373/clinchem.2012.194977. Epub 2012 Dec 11.
9
Iron for restless legs syndrome.
Cochrane Database Syst Rev. 2012 May 16;5(5):CD007834. doi: 10.1002/14651858.CD007834.pub2.
10
Evaluation of oral iron treatment in pediatric restless legs syndrome (RLS).
Sleep Med. 2012 Apr;13(4):429-32. doi: 10.1016/j.sleep.2011.12.009. Epub 2012 Feb 15.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验