Children's Minnesota Sleep Center, Children's Minnesota, St. Paul, Minnesota.
Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, Minnesota.
J Clin Sleep Med. 2019 Aug 15;15(8):1149-1154. doi: 10.5664/jcsm.7810.
To determine whether an oral iron supplement improves restless leg/restless sleep symptoms in a pediatric population.
In a cohort study, 47 patients (age 5-18 years) exhibiting restless legs/restless sleep symptoms and low serum ferritin levels (< 50 ng/mL) were given a daily oral iron supplement (ferrous sulfate + vitamin C) and re-evaluated 8 weeks later. A diagnosis of definite Restless Legs Syndrome (RLS) was determined based on criteria established by the International RLS Study Group. Using Wilcoxon signed-rank tests and Spearman rho, the change and association between the measures of Pediatric Restless Legs Syndrome Severity Scale and serum ferritin levels were also examined.
Overall, the median change and distribution of ferritin was statistically significantly different after 8 weeks of treatment (40.0 versus 23.0 ng/mL, P < .0001). Median RLS score was also statistically significantly lower from baseline to follow-up (4.0 versus 6.0, P = .0283). Sixteen patients met criteria for definite RLS; however, the change in RLS score was not determined to be significant in our population (9.5 versus 7.0, P = .0558), despite significant change in ferritin (25.0 versus 42.5 ng/mL, P < .0001). In addition, no correlation was observed between change in RLS score and ferritin level (rho = -.39, P = .1362).
In preliminary findings, we found a modest, yet nonsignificant improvement in children exhibiting restless sleep and RLS symptomatology, despite significant improvement in ferritin levels. Though not statistically significant, the findings can lend to the suggested benefit of iron supplementation in patients with RLS; however, clinical judgment and further research is necessary.
Rosen GM, Morrissette S, Larson A, Stading P, Barnes TL. Does improvement of low serum ferritin improve symptoms of restless legs syndrome in a cohort of pediatric patients? J Clin Sleep Med. 2019;15(8):1149-1154.
确定口服铁补充剂是否能改善儿科人群的不安腿/不安睡眠症状。
在一项队列研究中，47 名（5-18 岁）表现出不安腿/不安睡眠症状和低血清铁蛋白水平（<50ng/ml）的患者每天口服铁补充剂（硫酸亚铁+维生素 C），并在 8 周后重新评估。根据国际不安腿综合征研究组制定的标准，确定明确的不安腿综合征（RLS）诊断。使用 Wilcoxon 符号秩检验和 Spearman rho，还检查了儿科不安腿综合征严重程度量表和血清铁蛋白水平的测量值之间的变化和关联。
总体而言，治疗 8 周后铁蛋白的中位数变化和分布在统计学上有显著差异（40.0 与 23.0ng/ml，P<0.0001）。从基线到随访时，RLS 评分中位数也有统计学显著降低（4.0 与 6.0，P=0.0283）。16 名患者符合明确 RLS 的标准；然而，我们的人群中 RLS 评分的变化没有统计学意义（9.5 与 7.0，P=0.0558），尽管铁蛋白有显著变化（25.0 与 42.5ng/ml，P<0.0001）。此外，RLS 评分变化与铁蛋白水平之间未观察到相关性（rho=-0.39，P=0.1362）。
在初步研究结果中，我们发现尽管血清铁蛋白水平显著改善，但表现出不安睡眠和 RLS 症状的儿童有适度但无统计学意义的改善。尽管没有统计学意义，但这些发现可以证明铁补充对 RLS 患者的益处；然而，需要临床判断和进一步的研究。
Rosen GM，Morrissette S，Larson A，Stading P，Barnes TL。低血清铁蛋白水平改善是否能改善儿科患者不安腿综合征的症状？J 临床睡眠医学。2019；15（8）：1149-1154。
