Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, PUMC, Beijing, China.
Bioorg Med Chem Lett. 2012 Mar 15;22(6):2209-11. doi: 10.1016/j.bmcl.2012.01.102. Epub 2012 Feb 2.
Human enterovirus 71 infection causes hand, foot and mouth disease in children under 6 years of age and has caused mortalities in large-scale outbreaks in the Asia-Pacific region. No effective vaccine or antiviral drugs currently exist against enterovirus 71 in the clinic. In this study, we investigated the antiviral effect of geraniin on enterovirus 71 both in vitro and in vivo. The results showed that geraniin effectively inhibited virus replication in rhabdomyosarcoma cells with an IC(50) of 10 μg/ml. Moreover, geraniin treatment of mice that were challenged with a lethal dose of enterovirus 71 resulted in a reduction of mortality, relieved clinical symptoms, and inhibited virus replication in muscle tissues. The results suggest that geraniin may be used as a potential drug for anti-enterovirus 71.
人肠道病毒 71 型感染可引起 6 岁以下儿童手足口病，并在亚太地区的大规模暴发中导致死亡。目前临床上尚无针对肠道病毒 71 的有效疫苗或抗病毒药物。本研究从体内外水平评价了橙皮素抗肠道病毒 71 的作用。结果表明，橙皮素在横纹肌肉瘤细胞中能有效抑制病毒复制，IC50 为 10 μg/ml。此外，橙皮素处理致死剂量肠道病毒 71 攻击的小鼠，能降低死亡率，缓解临床症状，并抑制肌肉组织中的病毒复制。结果提示橙皮素可能作为抗肠道病毒 71 的潜在药物。
