Yang Yajun, Xiu Jinghui, Liu Jiangning, Zhang Li, Li Xiaoying, Xu Yanfeng, Qin Chuan, Zhang Lianfeng
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, PUMC, Beijing 100021, China.
Int J Mol Sci. 2013 May 3;14(5):9618-27. doi: 10.3390/ijms14059618.
Human enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. Presently, no vaccines or antiviral drugs have been clinically available to employ against EV71. In this study, we demonstrate that treatment with chebulagic acid reduced the viral cytopathic effect on rhabdomyosarcoma cells with an IC50 of 12.5 μg/mL. The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication. Chebulagic acid may represent a potential therapeutic agent to control infections to enterovirus 71.
人肠道病毒71型是6岁以下儿童手足口病的主要病原体之一。目前，尚无临床可用的疫苗或抗病毒药物来对抗肠道病毒71型。在本研究中，我们证明了诃子鞣酸处理可降低对横纹肌肉瘤细胞的病毒致细胞病变效应，其半数抑制浓度为12.5μg/mL。对用致死剂量肠道病毒71型攻击的小鼠使用诃子鞣酸处理，能够通过抑制病毒复制有效降低死亡率并缓解临床症状。诃子鞣酸可能是一种控制肠道病毒71型感染的潜在治疗剂。
