Faculty of Psychology, University of Warsaw, Warsaw, Poland.
Compr Psychiatry. 2012 Aug;53(6):789-96. doi: 10.1016/j.comppsych.2012.01.001. Epub 2012 Feb 15.
This is a study of the association between DRD4 exon III VNTR and DAT1 3'-untranslated region polymorphisms on the one hand and temperament assessed with the Formal Characteristics of Behaviour-Temperament Inventory on the other hand.
The study was run on 418 participants (314 women and 104 men) aged 18 to 55 years sampled from healthy male and female volunteers recruited from inhabitants of the Warsaw metropolis.
Main effects of sex were found for briskness (F(1,417) = 9.05, P = .003, η(2) = 0.022), perseveration (F(1,417) = 37.83, P < .001, η(2) = 0.085), sensory sensitivity (F(1,417) = 14.16, P < .001, η(2) = 0.003), and emotional reactivity (F(1,417) = 34.67, P < .001, η(2) = 0.078). A significant main effect of DAT1 variant was also found for sensory sensitivity (F(1,417) = 7.36, P = .007, η(2) = 0.018). No main effects of DRD4 on any of the analyzed temperament traits were found. A significant interaction of sex and DRD4 variant was found for sensory sensitivity (F(1,417) = 5.68, P = .018, η(2) = 0.014). No significant 3-way interactions (DAT1 × DRD4 × sex) were found.
A significant main effect of DAT1 polymorphism on sensory sensitivity and a significant interactive sex/DRD4 effect on that same trait were found.
本研究旨在探讨 DRD4 外显子 III VNTR 和 DAT1 3'-非翻译区多态性与使用行为-气质特征量表评估的气质之间的关系。
该研究纳入了 418 名年龄在 18 至 55 岁的参与者（314 名女性和 104 名男性），他们均来自于从华沙大都市居民中招募的健康男性和女性志愿者。
性别对冲动性（F(1,417) = 9.05，P =.003，η(2) = 0.022）、坚持性（F(1,417) = 37.83，P <.001，η(2) = 0.085）、感觉敏感性（F(1,417) = 14.16，P <.001，η(2) = 0.003）和情绪反应性（F(1,417) = 34.67，P <.001，η(2) = 0.078）存在主要影响。DAT1 变体对感觉敏感性也存在显著的主要影响（F(1,417) = 7.36，P =.007，η(2) = 0.018）。未发现 DRD4 对任何分析的气质特征存在主要影响。发现性别和 DRD4 变体之间存在显著的交互作用，表现为感觉敏感性（F(1,417) = 5.68，P =.018，η(2) = 0.014）。未发现 DAT1 × DRD4 × 性别 3 种因素的显著交互作用。
发现 DAT1 多态性对感觉敏感性存在显著的主要影响，以及性别/DRD4 对同一特征存在显著的交互影响。
