Kim Se Joo, Kim Young Shin, Kim Chan-Hyung, Lee Hong Shick
Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 2006 Dec 31;47(6):787-92. doi: 10.3349/ymj.2006.47.6.787.
Human personality traits have a considerable genetic component. Cloninger et al. were the first to postulate that certain personality traits, such as novelty seeking, are related to the dopamine neurotransmitter system. In this study, we investigated the associations between dopamine receptor D4 (DRD4) exon III and dopamine transporter (DAT1) polymorphisms and personality traits. The DRD4 and DAT1 gene polymorphisms were genotyped in 214 healthy Korean subjects, whose personality traits were assessed with the Temperament and Character Inventory (TCI). There were no significant differences between scores of TCI temperament dimensions (novelty seeking, harm avoidance, reward dependence, and persistence) and DRD4 gene polymorphism. The DAT1 gene polymorphisms also showed no significant association with any of the temperament subscales of the TCI. These data suggest that DRD4 and DAT1 gene polymorphism may not associated with personality traits in a Korean population.
人类人格特质具有相当大的遗传成分。克洛宁格等人首先提出，某些人格特质，如寻求新奇，与多巴胺神经递质系统有关。在本研究中，我们调查了多巴胺受体D4（DRD4）外显子III和多巴胺转运体（DAT1）多态性与人格特质之间的关联。对214名健康韩国受试者的DRD4和DAT1基因多态性进行了基因分型，并用气质与性格量表（TCI）评估了他们的人格特质。TCI气质维度（寻求新奇、避免伤害、奖赏依赖和坚持性）得分与DRD4基因多态性之间没有显著差异。DAT1基因多态性也与TCI的任何气质子量表均无显著关联。这些数据表明，DRD4和DAT1基因多态性可能与韩国人群的人格特质无关。
