Debevec M
Institute of Oncology, Ljubljana, Yugoslavia.
Neoplasma. 1990;37(5):601-6.
During the years 1973-1987, 75 patients were irradiated for brain metastases of unknown origin at the Institute of Oncology in Ljubljana. Of these, 35 (47%) were previously treated by surgery: Metastases were completely removed in 22 patients and partially in 7, whereas biopsy alone was performed in 6 patients. Based on the examinations carried out during radiation therapy and at the time of follow-up, the primary sites of tumor were established as follows: The lung in 40 patients, the breast in 2, melanoma in 2, and the esophagus, kidney, and parotid gland in one patient, respectively. Primary tumor could not be detected in 28 (37%) patients. Metastases were microscopically verified in 48 cases in which anaplastic carcinoma and adenocarcinoma were most frequent. All the patients were irradiated on a cobalt unit, generally with doses of 10 x 300 cGy in 2 weeks. Median survival of the 22 patients with total removal of brain metastases was 9.5 months, one-year survival being achieved in 41% of cases. In the remaining patients median survival was 3 months, whereas only 12% of the patients survived one year. The cause of death were most frequently, i.e. in 45 patients, brain metastases.
1973年至1987年期间，卢布尔雅那肿瘤研究所对75例原发灶不明的脑转移瘤患者进行了放射治疗。其中，35例（47%）患者此前接受过手术治疗：22例患者的转移瘤被完全切除，7例部分切除，6例仅进行了活检。根据放疗期间及随访时的检查，肿瘤的原发部位确定如下：40例为肺部，2例为乳腺，2例为黑色素瘤，1例分别为食管、肾脏和腮腺。28例（37%）患者未检测到原发肿瘤。48例患者的转移瘤经显微镜检查证实，其中间变性癌和腺癌最为常见。所有患者均在钴治疗机上接受放疗，一般在2周内给予10×300 cGy的剂量。22例脑转移瘤完全切除患者的中位生存期为9.5个月，41%的患者存活1年。其余患者的中位生存期为3个月，仅12%的患者存活1年。最常见的死亡原因是脑转移瘤，45例患者为此原因死亡。
