Solomon P R, Koota D, Pendlebury W W
Department of Psychology, Williams College, Williamstown, MA 01267.
Neurobiol Aging. 1990 Sep-Oct;11(5):523-8. doi: 10.1016/0197-4580(90)90113-e.
Rabbits were classically conditioned to emit an eyeblink conditioned response (CR) to electrical stimulation (ESB) of the medial geniculate nucleus (MGN) paired with a corneal air puff until they attained a criterion of two consecutive days of greater than 90% CRs. They then received intraventricular injections of 1% AlCl3, HCL, or normal saline. Ten days postinjection, each animal underwent a retention test consisting of 50 ESB alone presentations. Whereas all saline and HCL animals gave at least 90% CRs during retention, no aluminum rabbit emitted more than 30% CRs. Considered with the results of previous work, these data suggest that aluminum-induced neurofibrillary degeneration disrupts retention of the CR by affecting central associative processes.
对兔子进行经典条件反射训练，使其对与角膜吹气配对的内侧膝状体（MGN）电刺激（ESB）产生眨眼条件反应（CR），直至达到连续两天CR率大于90%的标准。然后给它们进行脑室内注射1%的氯化铝、盐酸或生理盐水。注射后十天，每只动物都接受了一次由50次单独的ESB呈现组成的记忆测试。在记忆测试期间，所有注射生理盐水和盐酸的动物至少有90%的CR率，而没有一只注射铝的兔子的CR率超过30%。结合之前的研究结果，这些数据表明铝诱导的神经原纤维变性通过影响中枢联想过程破坏了CR的记忆。
