Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Neurotoxicology. 2012 Jun;33(3):280-9. doi: 10.1016/j.neuro.2012.02.003. Epub 2012 Feb 11.
The role of green tea in protection against neurotoxicity induced by lead acetate was investigated in rats. Five equal groups, each of ten rats were used. The first group was served as control, the second, third, and fourth groups were given lead acetate, lead acetate and green tea, and green tea only, respectively, for one month, the fifth group was administered lead acetate for one month followed by green tea for 15 days. Lead acetate was given orally at a dose of 100 mg/kg b. wt, while green tea was given in drinking water at a concentration of 5 g/L. Lead acetate administration induced loss of body weight and decreased concentration of reduced glutathione and SOD activity in brain tissues as well as significantly high DNA fragmentation and pathological changes. Co-administration of green tea with lead acetate significantly alleviated these adverse effects.
研究了绿茶在预防醋酸铅诱导的神经毒性中的作用。使用了五组相等的大鼠，每组 10 只。第一组作为对照组，第二、三、四组分别给予醋酸铅、醋酸铅和绿茶以及仅绿茶，为期一个月。第五组先给予醋酸铅一个月，然后再给予绿茶 15 天。醋酸铅以 100mg/kg b.wt 的剂量口服给予，而绿茶以 5g/L 的浓度在饮用水中给予。醋酸铅给药导致体重减轻，脑组织中还原型谷胱甘肽和 SOD 活性降低，并且 DNA 片段化和病理变化显著增加。绿茶与醋酸铅联合给药可显著减轻这些不良反应。
