Kojima T, Waga S, Itoh H, Matsubara T, Kuga Y
Department of Neurosurgery, Mie University School of Medicine.
No Shinkei Geka. 1990 Oct;18(10):939-46.
It seems generally accepted that meningiomas are benign tumors, and that malignant meningiomas are not common. The pathological criteria for judging whether meningiomas are malignant or not are controversial. Hemangiopericytic type, high cellularity, brain invasion, high mitotic rate, necrotic foci, and papillary type are regarded as histological characteristics of malignant meningiomas. Of a series of 105 patients with surgically treated meningioma, 25 patients demonstrated malignant characteristics (24%). The overall recurrence rate in our patients was 14%. The incidence of recurrence in 25 patients with pathologically malignant characteristics, and recurrence in 80 patients with pathologically benign characteristics were 32% and 9%, respectively. In comparison with benign meningiomas, recurrent factors in malignant ones included Simpson grade II operation, attachment of skull base, and no radiation-therapy. In conclusion, our criteria for malignant meningiomas have proved to be acceptable, and these cases should be treated with radiation therapy after surgery.
一般认为脑膜瘤是良性肿瘤,恶性脑膜瘤并不常见。判断脑膜瘤是否为恶性的病理标准存在争议。血管外皮细胞瘤型、高细胞密度、脑侵犯、高有丝分裂率、坏死灶和乳头状型被视为恶性脑膜瘤的组织学特征。在一组105例接受手术治疗的脑膜瘤患者中,25例表现出恶性特征(24%)。我们患者的总体复发率为14%。25例具有病理恶性特征患者的复发率和80例具有病理良性特征患者的复发率分别为32%和9%。与良性脑膜瘤相比,恶性脑膜瘤的复发因素包括辛普森二级手术、颅底附着以及未进行放射治疗。总之,我们关于恶性脑膜瘤的标准已被证明是可接受的,这些病例术后应接受放射治疗。