Department of Medicine, University of Maryland School of Medicine, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA.
Curr Opin Oncol. 2012 May;24(3):266-71. doi: 10.1097/CCO.0b013e32835167fc.
This overview discusses several important developments in testicular germ cell tumors in the past year.
Genomic studies continue to investigate gene expression as possible markers for disease relapse and chemotherapy resistance. Optimal treatment strategies for early-stage seminomas are evolving toward surveillance versus chemotherapy and away from radiation, and the role of retroperitoneal lymph node dissection in disseminated nonseminomatous cancers in complete remission is becoming less certain.
Treatment and surveillance paradigms continue to be defined and refined for both early and late-stage disease as research in these areas continues and the data from multiple large studies mature.
本文概述了过去一年中睾丸生殖细胞肿瘤的几个重要进展。
基因组研究继续探索基因表达作为疾病复发和化疗耐药的可能标志物。早期精原细胞瘤的最佳治疗策略正在朝着监测与化疗而不是放疗的方向发展，腹膜后淋巴结清扫术在完全缓解的播散性非精原细胞瘤中的作用也变得不那么确定。
随着这些领域的研究不断深入，多项大型研究的数据不断成熟，早期和晚期疾病的治疗和监测模式仍在不断定义和完善。
