Department of Neonatology, Colorado Permanente Medical Group, Exempla Saint Joseph Hospital, Denver, CO, USA.
J Perinatol. 2012 Nov;32(11):880-5. doi: 10.1038/jp.2012.6. Epub 2012 Feb 16.
The definition of bronchopulmonary dysplasia (BPD) among very-low birth weight (VLBW) infants is based upon oxygen requirement at 36 weeks gestation, but oxygen may be required at altitude because of hypoxia. This study determined the effect of altitude on BPD rates.
For 63 VLBW infants at high altitude, oxygen concentrations were measured by a hood oxygenation test (HOT) and BPD rates were determined with altitude adjustment.
BPD rates before and after altitude adjustment were 71.8 and 26.7%, respectively. Of oxygen-dependent infants analyzed by HOT, 33.3% needed room air. HOT oxygen requirement correlated with gestational age of last apnea episode (r=0.42, P<0.001).
Although BPD rates may be adjusted for altitude with the HOT, the test does not accurately predict clinical oxygen need. Persistent requirement for supplemental oxygen beyond that needed in the HOT may be partially due to immaturity of respiratory control mechanisms.
极低出生体重儿（VLBW）支气管肺发育不良（BPD）的定义基于 36 周胎龄时的氧需求，但由于缺氧，高海拔地区可能需要吸氧。本研究旨在确定海拔高度对 BPD 发生率的影响。
对 63 例高海拔 VLBW 婴儿进行了 hood 氧合试验（HOT）以测量氧浓度，并通过海拔调整来确定 BPD 发生率。
调整海拔前后的 BPD 发生率分别为 71.8%和 26.7%。通过 HOT 分析需要吸氧的婴儿中，33.3%需要空气。HOT 氧需求与最后一次呼吸暂停发作时的胎龄呈正相关（r=0.42，P<0.001）。
尽管可以通过 HOT 调整海拔对 BPD 发生率的影响，但该试验并不能准确预测临床氧需求。除 HOT 所需的补充氧气外，持续需要额外的氧气可能部分是由于呼吸控制机制不成熟所致。
