University of Manchester, NIHR Translational Research Facility, Manchester Academic Health Science Centre, University Hospital South Manchester Foundation Trust, Manchester, UK.
Respiration. 2012;83(3):185-9. doi: 10.1159/000335993. Epub 2012 Feb 15.
Primary spontaneous pneumothorax (PSP) is by definition not associated with any underlying lung disease. However, this does not mean that there is no underlying pathological process. It has become increasingly apparent over recent years that PSP is associated with diffuse and often bilateral abnormalities within the pleura and is not simply a disease caused by ruptured blebs/bullae. The pathological process includes emphysema-like changes, pleural porosity and inflammation. In this review, we summarise the recent advances in our understanding of the pathogenesis of PSP and discuss how this relates to management strategies for patients with PSP.
原发性自发性气胸（PSP）从定义上讲与任何基础肺病无关。然而，这并不意味着没有潜在的病理过程。近年来，越来越明显的是，PSP 与胸膜内弥漫性且常常是双侧的异常有关，而不仅仅是由破裂的疱/大疱引起的疾病。病理过程包括肺气肿样改变、胸膜多孔性和炎症。在这篇综述中，我们总结了对 PSP 发病机制的理解的最新进展，并讨论了这与 PSP 患者的管理策略有何关系。
