Günebakmaz Ozgür, Celik Ahmet, Inanc M Tugrul, Duran Mustafa, Karakaya Ekrem, Tulmac Murat, Akpek Mahmut, Sarli Bahadir, Ergin Ali, Topsakal Ramazan
Department of Cardiology, Kastamonu Munif Islamoglu State Hospital, Kastamonu, Turkey.
Cardiology. 2011;120(4):221-6. doi: 10.1159/000335888. Epub 2012 Feb 14.
We aimed to investigate copeptin levels in mitral stenosis (MS) patients and the behavior of copeptin after hemodynamic improvement achieved by percutaneous balloon mitral valvuloplasty (PBMV). The study involved 29 consecutive symptomatic patients with moderate to severe rheumatic MS who underwent PBMV. Twenty-eight age- and gender-matched healthy volunteers composed the control group. Blood samples for copeptin were obtained immediately before and 24 h after PBMV, centrifuged, then stored at -70°C until assayed. The copeptin level of the patient group was statistically different from that of the control group (61.8 ± 34.4 and 36.8 ± 15.2 pg/ml, respectively; p = 0.001). PBMV resulted in a significant increase in mitral valve area and a significant decrease in transmitral gradient as well as systolic pulmonary artery pressure. While hemodynamic relief was obtained, we detected a statistically significant decline in copeptin levels 24 h after PBMV compared to the baseline levels (from 61.8 ± 34.4 to 44.1 ± 18.2 pg/ml; p = 0.004).
我们旨在研究二尖瓣狭窄（MS）患者的 copeptin 水平，以及经皮二尖瓣球囊成形术（PBMV）实现血流动力学改善后 copeptin 的变化情况。该研究纳入了 29 例连续的有症状的中重度风湿性 MS 患者，他们接受了 PBMV。28 名年龄和性别匹配的健康志愿者组成对照组。在 PBMV 前即刻和术后 24 小时采集 copeptin 的血样，离心后，储存于 -70°C 直至检测。患者组的 copeptin 水平与对照组有统计学差异（分别为 61.8±34.4 和 36.8±15.2 pg/ml；p = 0.001）。PBMV 导致二尖瓣面积显著增加，二尖瓣跨瓣压差以及收缩期肺动脉压显著降低。在获得血流动力学缓解的同时，我们检测到 PBMV 术后 24 小时 copeptin 水平与基线水平相比有统计学意义的下降（从 61.8±34.4 降至 44.1±18.2 pg/ml；p = 0.004）。
