Schultz W W, Weiss E
Am J Epidemiol. 1979 Aug;110(2):124-31. doi: 10.1093/oxfordjournals.aje.a112796.
Lynchburg fecal virus (LFV), originally isolated from the stool of an infectious hepatitis patient, was passaged 15 times in WI-38 cells and partially characterized. Its properties are as follows: RNA virus; 27 nm in diameter, picornavirus-like morphology; inactivated at 56 C for 60 minutes; resistant to treatment with hydrochloric acid (pH 3.0), chloroform (33%), and diethyl ether (20%). Neutralization studies indicated that LFV is antigenically related to coxsackievirus A-24 but not to prototype hepatitis A virus (HAV). The simultaneous occurrence of infections with LFV and with HAV was indicated by the results of enzyme immunoassay (EIA) of the sera of patients of the Lynchburg outbreak. Absence of anti-LFV in patient sera was accompanied by an absence of anti-HAV and, conversely, an increased titer in anti-LFV was accompanied by an increased titer in anti-HAV. Each antibody type was shown to be elicited independently indicating simultaneous infections with LFV and HAV. The contribution, if any, of LFV to disease in the outbreak remains unknown.
林奇堡粪便病毒（LFV）最初从一名传染性肝炎患者的粪便中分离出来，在WI-38细胞中传代15次并进行了部分特性鉴定。其特性如下：RNA病毒；直径27纳米，呈微小核糖核酸病毒样形态；在56℃下60分钟可被灭活；对盐酸（pH 3.0）、氯仿（33%）和乙醚（20%）处理具有抗性。中和试验表明，LFV与柯萨奇病毒A-24有抗原相关性，但与甲型肝炎病毒原型（HAV）无抗原相关性。林奇堡疫情患者血清的酶免疫分析（EIA）结果表明，LFV和HAV感染同时发生。患者血清中无抗LFV抗体与无抗HAV抗体同时出现，相反，抗LFV抗体效价升高与抗HAV抗体效价升高同时出现。每种抗体类型均显示为独立产生，表明LFV和HAV同时感染。LFV在此次疫情中对疾病的贡献（如果有）仍不清楚。
