Marconi Greg P, Ross Lawrence A, Nager Alan L
Divisions of Emergency and Transport Medicine, Children's Hospital Los Angeles, CA 90027, USA.
Pediatr Emerg Care. 2012 Mar;28(3):215-9. doi: 10.1097/PEC.0b013e318248b0cd.
The objective of the study was to review the 2010 pertussis upsurge occurring within California and recent experiences at a large tertiary care children's hospital within California.
A retrospective review of all specimens submitted for Bordetella pertussis polymerase chain reaction assay from the emergency department at a large tertiary care children's hospital from January 2009 to August 2010. Outcome measures were the number of specimens submitted, the number of positive specimens, and the percentage of positive specimens.
The last peak incidence of pertussis, in the Unite States, was seen in 2005 with an annual incidence of 25,616 reported cases. Comparing 2010 with 2009 during the same period, the total number of positive cases increased from 13 to 94, a 723% increase at our institution. The median monthly number of positive specimen was 1.5 for 2009 and 6.5 for 2010 (P = 0.0169).
Hospitals, private practitioners, and the California Department of Public Health need to emphasize prompt diagnosis and treatment of this contagious infection to limit the spread to susceptible individuals. A more widespread safe and effective vaccination program will hopefully enhance protection against pertussis infection.
本研究的目的是回顾加利福尼亚州2010年百日咳疫情的激增情况以及加利福尼亚州一家大型三级护理儿童医院的近期经验。
对2009年1月至2010年8月期间一家大型三级护理儿童医院急诊科提交的所有百日咳博德特氏菌聚合酶链反应检测标本进行回顾性分析。观察指标为提交的标本数量、阳性标本数量以及阳性标本的百分比。
美国上一次百日咳发病率高峰出现在2005年，报告病例的年发病率为25,616例。将2010年与同期的2009年进行比较，我院阳性病例总数从13例增加到94例，增长了723%。2009年阳性标本的月中位数为1.5，2010年为6.5（P = 0.0169）。
医院、私人执业医生和加利福尼亚州公共卫生部需要强调对这种传染性感染进行及时诊断和治疗，以限制其向易感人群的传播。更广泛的安全有效的疫苗接种计划有望增强对百日咳感染的防护。
