Sass K J, Spencer D D, Kim J H, Westerveld M, Novelly R A, Lencz T
Department of Surgery, Yale University School of Medicine, New Haven, CT 06510.
Neurology. 1990 Nov;40(11):1694-7. doi: 10.1212/wnl.40.11.1694.
Thirty-five patients with medically refractory epilepsy localized to the temporal lobe (18 left, 17 right) completed the verbal Selective Reminding Test before surgery. Verbal memory impairments existed before surgery regardless of the lateralization of the seizure focus, but patients with left temporal seizure foci were significantly more impaired. After surgical removal of the mesial temporal lobe structures, 2 blinded observers established volumetric cell densities for hippocampal subfields CA1, CA2, CA3, the hilar area, and the granule cell layer of the area dentata. Statistically significant correlations existed between presurgical memory impairment and cell counts (in CA3 and the hilar area, only) for patients with left temporal seizure foci. These findings support the hippocampal model of memory and complement prior research documenting the memory impairments present after surgical removal of the mesial temporal structures.
35例药物难治性颞叶癫痫患者（18例左侧，17例右侧）在手术前完成了言语选择性提醒测试。无论癫痫病灶的定位如何，术前均存在言语记忆障碍，但左侧颞叶癫痫病灶的患者受损明显更严重。在手术切除内侧颞叶结构后，2名盲法观察者确定了海马亚区CA1、CA2、CA3、海马门区和齿状回颗粒细胞层的体积细胞密度。对于左侧颞叶癫痫病灶的患者，术前记忆障碍与细胞计数（仅在CA3和海马门区）之间存在统计学上的显著相关性。这些发现支持了记忆的海马模型，并补充了先前关于内侧颞叶结构手术切除后出现记忆障碍的研究。
