Harvard Medical School, Boston, MA 02115, USA.
Sci Transl Med. 2012 Feb 15;4(121):121ps3. doi: 10.1126/scitranslmed.3003492.
Here, we synthesize research behind the emerging hypothesis that inflammation--which can result, for example, from viral infections--can initiate and propagate chronic neuronal dysfunction, an event that precedes the clinical onset of many neurodegenerative diseases. Therapeutic approaches that target immunological pathways in the prodromal phase of diseases might decrease the incidence of neurodegenerative disorders and increase the therapeutic window for neuroprotection.
在这里，我们综合了炎症（例如由病毒感染引起）可能引发和传播慢性神经元功能障碍这一新兴假说的研究进展。这种情况发生在许多神经退行性疾病的临床症状出现之前。在疾病的前驱期针对免疫途径的治疗方法可能会降低神经退行性疾病的发病率，并增加神经保护的治疗窗口。
