Lombardi C, Missale C, Poli M, De Cotiis R, Memo M, Spedini C, Spano P F
Divisione di Medicina Interna, Ospedale S. Orsola, Brescia, Italia.
Minerva Med. 1990 Sep;81(9):587-90.
Recent studies have shown a possible role of different factors in the regulation of prolactin secretion. In fact many neurotransmitters (dopamine) and peptides can modulate prolactin release from anterior pituitary lactotrophs. In vitro and in vivo studies, Angiotensin II has been shown to increase prolactin release. On the basis of these data we have studied the effects of enalapril (ACE-Inhibitor) on baseline plasma prolactin in nine hypertensive post-menopausal women. The results indicate that 15-day inhibition of angiotensin-converting enzyme by enalapril significantly reduced serum prolactin levels. These data suggest that the Angiotensin II may play a role in the control of prolactin secretion in hypertensive women.
近期研究表明，不同因素在催乳素分泌调节中可能发挥作用。事实上，许多神经递质（多巴胺）和肽类能够调节垂体前叶催乳细胞释放催乳素。体外和体内研究均显示，血管紧张素II可增加催乳素释放。基于这些数据，我们研究了依那普利（一种血管紧张素转换酶抑制剂）对9名绝经后高血压女性基础血浆催乳素水平的影响。结果表明，依那普利对血管紧张素转换酶进行15天的抑制可显著降低血清催乳素水平。这些数据提示，血管紧张素II可能在高血压女性催乳素分泌的调控中发挥作用。
