Yoldi A, Monreal M, Recio J M, Oleaga A, Salvador J, Moncada E
Dpto. Endocrinología, Clínica Universitaria de Navarra.
Rev Med Univ Navarra. 1992 Oct-Dec;37(4):191-8.
The identification of elements of the renin-angiotensin system and ulterior demonstration of specific cellular angiotensin II (Ag II) receptors at hypothalamic-pituitary level has suggested the possibility that these peptide play a modulatory role on anterior pituitary secretion. Recent "in vivo" and "in vitro" studies provided confirmation of a stimulatory effect of the renin-angiotensin system on growth hormone (GH) and ACTH variable. Initial experiments indicate that there is no effect on TSH and gonadotrophins secretion. Treatment with angiotensin-converting enzyme inhibitors leads to a reduction of Ag II levels that results in slight decrease of PRL and GH concentrations. However, the mechanism by which Ag II is able to modulate anterior pituitary secretion still remains obscure. Both, indirect effects mediated through changes in neuropeptide secretion or a direct interaction on pituitary cells by a paracrine or endocrine mechanism emerge as possible hypothesis to explain this regulatory function.
肾素-血管紧张素系统各成分的鉴定以及随后在下丘脑-垂体水平发现特定的细胞血管紧张素II（Ag II）受体，提示了这些肽可能对垂体前叶分泌起调节作用。最近的“体内”和“体外”研究证实了肾素-血管紧张素系统对生长激素（GH）和促肾上腺皮质激素（ACTH）分泌有刺激作用。初步实验表明，该系统对促甲状腺激素（TSH）和促性腺激素的分泌没有影响。用血管紧张素转换酶抑制剂治疗会导致Ag II水平降低，进而使催乳素（PRL）和GH浓度略有下降。然而，Ag II调节垂体前叶分泌的机制仍不清楚。通过神经肽分泌变化介导的间接作用，或通过旁分泌或内分泌机制对垂体细胞的直接相互作用，都可能是解释这种调节功能的假说。
