Institute of Organic Chemistry, University of Zurich, Switzerland.
Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3466-9. doi: 10.1002/anie.201108018. Epub 2012 Feb 17.
The missing linking: BCNU is a chemotherapy drug that generates an ethylene bridge between N(1) of deoxyguanosine and N(3) of deoxycytidine. No synthesis of a DNA containing this moiety has been reported until now. A new strategy uses a photocaged nucleobase that, when released, generates a highly reactive intermediate which cross-links the opposing DNA strand in a manner analogous to BCNU.
卡莫司汀是一种化疗药物，它在脱氧鸟嘌呤的 N(1)和脱氧胞嘧啶的 N(3)之间生成一个乙烯桥。到目前为止，还没有报道过含有这种部分的 DNA 的合成。一种新的策略使用光解笼蔽碱基，当它被释放时，会产生一种高反应性的中间体，以类似于卡莫司汀的方式交联相反的 DNA 链。
