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[中缅树鼩神经肽Y的分子克隆及其与灵长类动物其他类似物的同源性比较]

[Molecular cloning of Tupaia belangeri chinensis neuropeptide Y and homology comparison with other analogues from primates].

作者信息

Dong Li, Lv Long-Bao, Lai Ren

机构信息

Chinese Academy of Sciences, Kunming, China.

出版信息

Dongwuxue Yanjiu. 2012 Feb;33(1):75-8. doi: 10.3724/SP.J.1141.2012.01075.

Abstract

Much attention has been payed to tree shrews for their close phylogenetic relationship with primates, small size, and short reproductive cycle. Especially, they are considered as excellent experiential animals for medicine or/and disease research. A nucleotide sequence encoding neuropeptide Y(NPY) precursor has been cloned from the cDNA library of Tupaia belangeri chinensis. Sequence alignment revealed that the sequence homology with primate NPY was up to 96.9%. The phylogenetic analysis based on NPY precursor sequence revealed that the tree shrew has a close relationship with primates.

摘要

树鼩因其与灵长类动物相近的系统发育关系、体型小和繁殖周期短而备受关注。特别是,它们被认为是医学或/和疾病研究的优秀实验动物。从中国树鼩的cDNA文库中克隆了编码神经肽Y(NPY)前体的核苷酸序列。序列比对显示,与灵长类NPY的序列同源性高达96.9%。基于NPY前体序列的系统发育分析表明,树鼩与灵长类动物关系密切。

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