高胰岛素血症对正常血糖清醒大鼠局部脑胰岛素结合及葡萄糖利用的影响。

Effects of hyperinsulinemia on local cerebral insulin binding and glucose utilization in normoglycemic awake rats.

作者信息

Marfaing P, Penicaud L, Broer Y, Mraovitch S, Calando Y, Picon L

机构信息

Laboratoire de Physiologie du Développement, CNRS UA 307, Université Paris VII, France.

出版信息

Neurosci Lett. 1990 Jul 31;115(2-3):279-85. doi: 10.1016/0304-3940(90)90469-p.

DOI:10.1016/0304-3940(90)90469-p

PMID:2234506

Abstract

The present study was carried out to characterize the effects of insulin, using the euglycemic hyperinsulinemic clamp, on insulin binding and glucose utilization in specific areas of rat brain, by autoradiographic methods. Binding of [125I]Insulin was significantly higher in the hippocampus CA1, the ventromedial and lateral hypothalamus nuclei of the hyperinsulinemic rats than in control rats. Glucose utilization was slightly but not significantly decreased in the hippocampus CA1, the ventromedial and lateral hypothalamus of hyperinsulinemic rats. These data suggest that insulin, via its specific receptors, may exert its central actions by affecting glucose utilization.

摘要

本研究采用正常血糖高胰岛素钳夹技术，通过放射自显影方法，旨在表征胰岛素对大鼠脑特定区域胰岛素结合及葡萄糖利用的影响。高胰岛素血症大鼠海马CA1区、腹内侧和外侧下丘脑核团中[125I]胰岛素的结合显著高于对照大鼠。高胰岛素血症大鼠海马CA1区、腹内侧和外侧下丘脑的葡萄糖利用略有下降，但无显著差异。这些数据表明，胰岛素可能通过其特定受体，通过影响葡萄糖利用来发挥其中枢作用。