University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany.
J Leukoc Biol. 2012 Jul;92(1):75-82. doi: 10.1189/jlb.1011530. Epub 2012 Feb 17.
Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus-host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.
程序性细胞死亡是在感染 IV 的组织中经常观察到的一种重要的细胞反应。本文综述了目前关于分子病毒-宿主相互作用的知识，这些相互作用诱导感染 IV 的细胞中的凋亡途径，以及这些细胞信号事件对病毒在病毒复制周期的不同阶段的增殖的功能意义。此外，本文还总结了 IV 诱导的凋亡途径在平衡宿主抗病毒免疫反应方面的作用，即在有效清除病毒和发展严重凋亡性肺损伤之间取得平衡。
