• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

评价甲状腺激素诱导的药物预处理对心肌细胞缺血再灌注损伤的保护作用。

Evaluation of thyroid hormone induced pharmacological preconditioning on cardiomyocyte protection against ischemic-reperfusion injury.

机构信息

Department of Pharmacology, I. S. F. College of Pharmacy, Moga, Punjab, India.

出版信息

Indian J Pharmacol. 2012 Jan;44(1):68-72. doi: 10.4103/0253-7613.91870.

DOI:10.4103/0253-7613.91870
PMID:22345873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3271543/
Abstract

OBJECTIVES

Ischemic preconditioning (IPC) has been demonstrated to make myocardium transiently more resistant to deleterious effect of prolonged ischemia. The opening of the mitochondrial permeability transition pore (mPTP) at the time of myocardial reperfusion is a critical determinant of cell death. L-thyroxine pre-treatment increases the tolerance of the heart to ischemia and produces cardioprotection similar to ischemic precondition. This study has been designed to investigate the mechanism involved in L-thyroxine-induced cardiomyocyte protection against ischemia-reperfusion (I/R) injury in rats.

MATERIALS AND METHODS

L-thyroxine (T(4)) was administered to Wistar rats (n=6) (25 μg/100 g/day s.c.) for two weeks. Hearts from normal and L-thyroxine-treated rats were perfused in Langendorff's mode and subjected to 30 min of ischemia followed by 120 min of reperfusion. Myocardial infarct size was estimated by triphenyltetrazolium chloride (TTC) staining and lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) was analyzed in coronary effluent.

RESULTS

IPC and pharmacological preconditioning (PPC) significantly decreased (P<0.05) myocardial infarct size, release of LDH and CK-MB in rat heart. Perfusion of atractyloside, an opener of mPTP, significantly (P<0.05) attenuated the cardioprotective effect of IPC and L-thyroxine-induced pharmacological preconditioning (PPC) in normal rat heart.

CONCLUSION

The cardioprotective effect of L-thyroxine-induced preconditioning may be mediated through inhibition of mPTP opening during reperfusion phase.

摘要

目的

缺血预处理（IPC）已被证明可使心肌在短暂时间内对延长的缺血产生的有害影响更具抗性。心肌再灌注时线粒体通透性转换孔（mPTP）的开放是细胞死亡的关键决定因素。左甲状腺素预处理可增加心脏对缺血的耐受性，并产生类似于缺血预处理的心脏保护作用。本研究旨在探讨左甲状腺素诱导的心肌细胞对大鼠缺血再灌注（I/R）损伤的保护机制。

材料和方法

将左甲状腺素（T4）（25μg/100g/天 sc）给予 Wistar 大鼠（n=6）两周。正常和左甲状腺素处理的大鼠心脏在 Langendorff 模式下进行灌注，并经历 30 分钟的缺血，随后进行 120 分钟的再灌注。通过三苯基四氮唑氯化物（TTC）染色估计心肌梗死面积，并分析冠状动脉流出液中的乳酸脱氢酶（LDH）和肌酸激酶-MB（CK-MB）。

结果

IPC 和药物预处理（PPC）显著降低了（P<0.05）大鼠心脏的心肌梗死面积、LDH 和 CK-MB 的释放。mPTP 开放剂曲古抑菌素 A 的灌注显著（P<0.05）减弱了 IPC 和左甲状腺素诱导的药物预处理（PPC）对正常大鼠心脏的心脏保护作用。

结论

左甲状腺素诱导的预处理的心脏保护作用可能是通过抑制再灌注期间 mPTP 的开放介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ee/3271543/ae07aafeda3a/IJPharm-44-68-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ee/3271543/ae07aafeda3a/IJPharm-44-68-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9ee/3271543/ae07aafeda3a/IJPharm-44-68-g001.jpg

相似文献

1
Evaluation of thyroid hormone induced pharmacological preconditioning on cardiomyocyte protection against ischemic-reperfusion injury.评价甲状腺激素诱导的药物预处理对心肌细胞缺血再灌注损伤的保护作用。
Indian J Pharmacol. 2012 Jan;44(1):68-72. doi: 10.4103/0253-7613.91870.
2
Modulation of the cardioprotective effect of ischemic preconditioning in hyperlipidaemic rat heart.高脂血症大鼠心脏缺血预处理的心脏保护作用的调节。
Eur J Pharmacol. 2010 Sep 15;643(1):78-83. doi: 10.1016/j.ejphar.2010.06.015. Epub 2010 Jun 20.
3
Involvement of GSK-3β in attenuation of the cardioprotective effect of ischemic preconditioning in diabetic rat heart.糖原合成酶激酶-3β（GSK-3β）参与糖尿病大鼠心脏缺血预处理保护效应减弱。
Mol Cell Biochem. 2010 Oct;343(1-2):75-81. doi: 10.1007/s11010-010-0500-z. Epub 2010 May 30.
4
Possible role of JAK-2 in attenuated cardioprotective effect of ischemic preconditioning in hyperhomocysteinemic rat hearts.JAK-2在高同型半胱氨酸血症大鼠心脏中缺血预处理减弱的心脏保护作用中的可能作用。
Yakugaku Zasshi. 2009 May;129(5):523-35. doi: 10.1248/yakushi.129.523.
5
Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore.1-磷酸鞘氨醇诱导糖尿病大鼠心脏对缺血/再灌注损伤产生心脏保护作用的机制：糖原合酶激酶3β和线粒体通透性转换孔可能的参与情况
Clin Exp Pharmacol Physiol. 2016 Feb;43(2):166-73. doi: 10.1111/1440-1681.12516.
6
Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts.PKC-δ 的可能参与导致高同型半胱氨酸血症大鼠心脏缺血预处理的心脏保护作用减弱。
Biomed Pharmacother. 2010 Mar;64(3):195-202. doi: 10.1016/j.biopha.2009.04.030. Epub 2009 Oct 17.
7
Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts.腺嘌呤核苷 A1 受体的激活可恢复高同型半胱氨酸血症大鼠心脏中缺血预处理抑制的心脏保护作用。
J Cardiovasc Pharmacol. 2009 Sep;54(3):204-12. doi: 10.1097/FJC.0b013e3181b04cc5.
8
Effect of zinc supplements in the attenuated cardioprotective effect of ischemic preconditioning in hyperlipidemic rat heart.锌补充剂对高脂血症大鼠心脏缺血预处理减弱的心脏保护作用的影响。
Naunyn Schmiedebergs Arch Pharmacol. 2015 Jun;388(6):635-41. doi: 10.1007/s00210-015-1105-6. Epub 2015 Mar 7.
9
Phenylephrine induces early and late cardioprotection through mitochondrial permeability transition pore in the isolated rat heart.苯肾上腺素通过线粒体通透性转换孔诱导分离大鼠心脏的早期和晚期心脏保护作用。
J Surg Res. 2010 Nov;164(1):e37-42. doi: 10.1016/j.jss.2010.04.060. Epub 2010 May 26.
10
Possible involvement of caveolin in attenuation of cardioprotective effect of ischemic preconditioning in diabetic rat heart.可能涉及窖蛋白在糖尿病大鼠心脏缺血预处理保护作用减弱中的作用。
BMC Cardiovasc Disord. 2011 Jul 12;11:43. doi: 10.1186/1471-2261-11-43.

引用本文的文献

1
Effect of Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury.冷适应对心血管系统状态和心脏对缺血/再灌注损伤的耐受性的影响。
Iran Biomed J. 2024 Mar 1;28(2&3):59-70. doi: 10.61186/ibj.3872.
2
Preoperative oral thyroid hormones to prevent euthyroid sick syndrome and attenuate myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass in children: A randomized, double-blind, placebo-controlled trial.术前口服甲状腺激素预防儿童体外循环心脏手术后的正常甲状腺病态综合征并减轻心肌缺血再灌注损伤：一项随机、双盲、安慰剂对照试验。
Medicine (Baltimore). 2018 Sep;97(36):e12100. doi: 10.1097/MD.0000000000012100.
3

本文引用的文献

1
Possible involvement of α1-adrenergic receptor and K(ATP) channels in cardioprotective effect of remote aortic preconditioning in isolated rat heart.α1-肾上腺素能受体和K(ATP)通道可能参与离体大鼠心脏远程主动脉预处理的心脏保护作用。
J Cardiovasc Dis Res. 2010 Jul;1(3):145-51. doi: 10.4103/0975-3583.70917.
2
Protein kinase C subtypes and retinal ischemic preconditioning.蛋白激酶C亚型与视网膜缺血预处理
Exp Eye Res. 2008 Oct;87(4):300-11. doi: 10.1016/j.exer.2008.05.015. Epub 2008 Jun 3.
3
Isolated heart perfusion according to Langendorff---still viable in the new millennium.
T₃-induced liver AMP-activated protein kinase signaling: redox dependency and upregulation of downstream targets.
三碘甲状腺原氨酸诱导的肝脏AMP活化蛋白激酶信号传导：氧化还原依赖性及下游靶点的上调
World J Gastroenterol. 2014 Dec 14;20(46):17416-25. doi: 10.3748/wjg.v20.i46.17416.
4
Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit.曲匹地尔对兔心肌缺血-再灌注损伤的影响。
Indian J Pharmacol. 2014 Mar-Apr;46(2):207-10. doi: 10.4103/0253-7613.129320.
根据朗格多夫法进行的离体心脏灌注——在新千年仍可行。
J Pharmacol Toxicol Methods. 2007 Mar-Apr;55(2):113-26. doi: 10.1016/j.vascn.2006.05.006. Epub 2006 May 26.
4
Thyroid hormone receptors alpha1 and beta1 are downregulated in the post-infarcted rat heart: consequences on the response to ischaemia-reperfusion.甲状腺激素受体α1和β1在大鼠心肌梗死后下调：对缺血再灌注反应的影响。
Basic Res Cardiol. 2005 Sep;100(5):422-32. doi: 10.1007/s00395-005-0545-4.
5
Thyroid hormone and phenotypes of cardioprotection.甲状腺激素与心脏保护的表型
Basic Res Cardiol. 2004 Mar;99(2):101-20. doi: 10.1007/s00395-003-0449-0. Epub 2003 Nov 28.
6
Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.心肌再灌注期间线粒体通透性转换孔开放——心脏保护的一个靶点。
Cardiovasc Res. 2004 Feb 15;61(3):372-85. doi: 10.1016/S0008-6363(03)00533-9.
7
A routine method for the estimation of lactic dehydrogenase activity.一种估算乳酸脱氢酶活性的常规方法。
J Med Lab Technol. 1959 Oct;16:265-72.
8
A method for the estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase activity in normal and pathological sera.一种血清肌酸激酶的估算方法及其在比较正常和病理血清中肌酸激酶与醛缩酶活性方面的应用。
Clin Chim Acta. 1962 Sep;7:597-603. doi: 10.1016/0009-8981(62)90137-7.
9
Role of mitochondrial KATP channels and protein kinase C in ischaemic preconditioning.线粒体ATP敏感性钾通道和蛋白激酶C在缺血预处理中的作用
Clin Exp Pharmacol Physiol. 2003 May-Jun;30(5-6):426-36. doi: 10.1046/j.1440-1681.2003.03853.x.
10
Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart.缺血预处理可抑制再灌注大鼠心脏线粒体通透性转换孔的开放。
J Physiol. 2003 Jun 1;549(Pt 2):513-24. doi: 10.1113/jphysiol.2003.034231. Epub 2003 Apr 11.