Oriental Medicine R&D Center, Dongguk University, Gyeongju, Republic of Korea.
Indian J Pharmacol. 2012 Jan;44(1):97-102. doi: 10.4103/0253-7613.91877.
Wen-pi-tang-Hab-Wu-ling-san (WHW) is an oriental herbal prescription formulated using 14 herbs and has been used to cure chronic renal failure in Korean oriental medicine. In this study, we investigated the anti-diabetic effect of WHW in the streptozotocin-induced diabetic rats.
Diabetes was induced by streptozotocin (STZ, 60 mg/kg, i.p.) in rats. WHW extract (100 mg/kg) was orally dosed once a day for four weeks. The results were compared with standard antidiabetic drug, glibenclamide (3 mg/kg, p.o).
Significant decrease in body weight and insulin levels and increase in blood glucose, triglycerides, urea nitrogen (BUN), and creatinine were detected in STZ-induced diabetic rats with disruption and disappearance of pancreatic and kidney cells and decrease in insulin producing beta cells. However, these diabetic changes were significantly inhibited by treatment with WHW extract. In the oral glucose tolerance test, the extract produced a significant decrease in glycemia 60 minutes after the glucose pulse.
Based on these results, we suggest that WHW extract has favorable effects in protecting the STZ-induced hyperglycemia, renal damage, and beta-cell damage in rats.
温脾汤合五苓散（WHW）是一种由 14 种草药组成的东方草药配方，已被用于治疗韩国东方医学中的慢性肾衰竭。在这项研究中，我们研究了 WHW 在链脲佐菌素诱导的糖尿病大鼠中的抗糖尿病作用。
糖尿病通过链脲佐菌素（STZ，60mg/kg，ip）在大鼠中诱导。WHW 提取物（100mg/kg）每天口服一次，持续四周。结果与标准抗糖尿病药物格列本脲（3mg/kg，po）进行比较。
在 STZ 诱导的糖尿病大鼠中，体重和胰岛素水平显著下降，血糖、甘油三酯、尿素氮（BUN）和肌酐升高，胰腺和肾脏细胞破坏和消失，胰岛素产生β细胞减少。然而，这些糖尿病变化被 WHW 提取物的治疗显著抑制。在口服葡萄糖耐量试验中，提取物在葡萄糖脉冲后 60 分钟时使血糖显著降低。
基于这些结果，我们认为 WHW 提取物对保护 STZ 诱导的大鼠高血糖、肾损伤和β细胞损伤具有良好的作用。
