Alfarra Helmi Y, Alfarra Sabreen R, Sadiq Mai F
Department of Biological Sciences, Yarmouk University, Irbid, Jordan.
Indian J Hum Genet. 2011 Sep;17(3):126-31. doi: 10.4103/0971-6866.92082.
Neural tube defects (NTDs) are the second most common severely disabling human congenital defects. Worldwide, NTDs incidence is approximately one per 1000 live births and varies between 0.78 and 12 per 1000 births in general populations. NTDs causation involves multiple genes, nutritional and environmental factors. Research in the next stage should include bigger populations and bigger studies that would be suitable to detect significant links and conclusions with relatively minor risk factors; analysis of multiple candidate genes to detect potential gene-gene interactions; detailed analysis of patient samples stratified by phenotype.
神经管缺陷（NTDs）是人类第二常见的严重致残先天性缺陷。在全球范围内，NTDs的发病率约为每1000例活产中有1例，在普通人群中每1000例出生的发病率在0.78至12例之间。NTDs的病因涉及多个基因、营养和环境因素。下一阶段的研究应包括更大规模的人群和更大型的研究，以适合检测与相对较小风险因素之间的显著关联和结论；分析多个候选基因以检测潜在的基因-基因相互作用；对按表型分层的患者样本进行详细分析。
