关于宿主对人乳头瘤病毒感染及进展为宫颈癌的遗传易感性的综合综述。
A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer.
作者信息
Chattopadhyay Koushik
机构信息
Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, Republic of South Africa.
出版信息
Indian J Hum Genet. 2011 Sep;17(3):132-44. doi: 10.4103/0971-6866.92087.
Abstract
Cervical cancer is the second most common cancer in women worldwide. This is caused by oncogenic types of human papillomavirus (HPV) infection. Although large numbers of young sexually active women get HPV-infected, only a small fraction develop cervical cancer. This points to different co-factors for regression of HPV infection or progression to cervical cancer. Host genetic factors play an important role in the outcome of such complex or multifactor diseases such as cervical cancer and are also known to regulate the rate of disease progression. The aim of this review is to compile the advances in the field of host genetics of cervical cancer. MEDLINE database was searched using the terms, 'HPV', 'cervical', 'CIN', 'polymorphism(s)', 'cervical'+ the name of the gene and 'HPV'+ the name of the gene. This review focuses on the major host genes reported to affect the progression to cervical cancer in HPV infected individuals.
摘要
宫颈癌是全球女性中第二常见的癌症。这是由致癌型人乳头瘤病毒（HPV）感染引起的。尽管大量年轻的性活跃女性会感染HPV，但只有一小部分会发展为宫颈癌。这表明HPV感染消退或发展为宫颈癌存在不同的共同因素。宿主遗传因素在宫颈癌等复杂或多因素疾病的发生发展中起着重要作用，并且已知其可调节疾病进展速度。本综述的目的是汇总宫颈癌宿主遗传学领域的进展。使用“HPV”、“宫颈”、“CIN”、“多态性”、“宫颈” + 基因名称以及“HPV” + 基因名称等检索词在MEDLINE数据库中进行了检索。本综述重点关注据报道会影响HPV感染个体发展为宫颈癌的主要宿主基因。
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