Chotipanich Adit, Siriarechakul Surattaya, Mungkung On-Ong
Head and Neck Unit, Chonburi Cancer Hospital, Department of Medical Services, Ministry of Public Health, Chonburi, Thailand.
Head and Neck Unit, Lopburi Cancer Hospital, Department of Medical Services, Ministry of Public Health, Lopburi, Thailand.
SAGE Open Med. 2018 Mar 19;6:2050312118765604. doi: 10.1177/2050312118765604. eCollection 2018.
Among developing countries, Thailand shows no increase in the incidence of human papillomavirus-driven oropharyngeal cancer. The causal role of human papillomavirus infection in this pathology has not been researched thoroughly.
A hospital-based, case-control study was performed which included 104 patients with newly diagnosed oral and oropharyngeal squamous cell carcinomas and 104 individuals without cancer. The Cervista high-risk human papillomavirus and 16/18 assays were used to detect human papillomavirus. Odds ratios were used to assess the association between high-risk genotypes of human papillomavirus and the cancers.
High-risk human papillomavirus was detected in 4 of 52 (7.7%) oral cancer cases, 6 of 52 (11.5%) oropharyngeal cancer cases, and 1 of 104 (0.96%) control subjects. Of 104 cancer patients in the study, 83 were smokers. High-risk human papillomavirus was significantly associated with oropharyngeal cancer (odds ratio = 13.44, 95% confidence interval = 1.6-114.8) but was nonsignificantly associated with oral cancer (odds ratio = 8.58, 95% confidence interval = 0.9-78.9). However, after adjustment for smoking, high-risk human papillomavirus was determined to be nonsignificantly associated with oropharyngeal cancer (adjusted odds ratio = 5.83, 95% confidence interval = 0.8-43.5).
Although low human papillomavirus prevalence was observed, the rate of high-risk human papillomavirus infection in the cancer group was still higher than that in the control group. Smoking may have an influence on the etiology of human papillomavirus-related cancers. However, the study is underpowered to clarify the role of human papillomavirus as the independent risk factor for oral and oropharyngeal cancers in the Thai population.
在发展中国家中，泰国人乳头瘤病毒驱动的口咽癌发病率未见上升。人乳头瘤病毒感染在这种病理状况中的因果作用尚未得到充分研究。
开展了一项基于医院的病例对照研究，纳入104例新诊断的口腔和口咽鳞状细胞癌患者以及104名无癌症个体。采用Cervista高危人乳头瘤病毒和16/18检测法检测人乳头瘤病毒。比值比用于评估人乳头瘤病毒高危基因型与癌症之间的关联。
在52例口腔癌病例中有4例（7.7%）检测到高危人乳头瘤病毒，52例口咽癌病例中有6例（11.5%），104名对照对象中有1例（0.96%）。该研究中的104例癌症患者中，83例为吸烟者。高危人乳头瘤病毒与口咽癌显著相关（比值比 = 13.44，95%置信区间 = 1.6 - 114.8），但与口腔癌的关联不显著（比值比 = 8.58，95%置信区间 = 0.9 - 78.9）。然而，在对吸烟进行校正后，高危人乳头瘤病毒被确定与口咽癌的关联不显著（校正比值比 = 5.83，95%置信区间 = 0.8 - 43.5）。
尽管人乳头瘤病毒总体感染率较低，但癌症组中的高危人乳头瘤病毒感染率仍高于对照组。吸烟可能对人乳头瘤病毒相关癌症的病因有影响。然而，该研究的效能不足以阐明人乳头瘤病毒作为泰国人群口腔和口咽癌独立危险因素的作用。
