Pantelides Nicholas M, Ivaz Stella L, Falconer Alison, Hazell Steven, Winkler Mathias, Hrouda David, Mayer Erik K
Department of Urology, Charing Cross Hospital, London, UK.
Urol Ann. 2012 Jan;4(1):45-7. doi: 10.4103/0974-7796.91626.
Lymphoepithelioma-like carcinoma (LELC) of the urinary bladder is a rare variant, which can occur in a pure form or in conjunction with transitional cell carcinoma. Owing to the scarcity of reported cases, the optimum treatment is yet to be defined, although the benefits of chemotherapy are increasingly recognised. We present a case of a 64-year-old man with pure LELC, treated with trans-urethral resection of the bladder tumor (TURBT) and primary gemcitabine and platinum-based chemotherapy. He remained free of disease at six-month follow-up cystoscopy. The case adds to the growing evidence for the efficacy of chemotherapy, coupled with TUR, as part of a bladder-preserving treatment option for LELC.
膀胱淋巴上皮瘤样癌(LELC)是一种罕见的变体,可呈纯形式出现或与移行细胞癌同时发生。由于报告的病例稀少,尽管化疗的益处越来越得到认可,但最佳治疗方法尚未确定。我们报告一例64岁男性的纯LELC病例,该患者接受了经尿道膀胱肿瘤切除术(TURBT)以及吉西他滨和顺铂为主的化疗。在六个月的随访膀胱镜检查中,他未出现疾病复发。该病例进一步证明了化疗联合经尿道切除术作为LELC保膀胱治疗方案一部分的有效性,相关证据越来越多。