Park Mi Kyung, Kim Hyun Kyu, Park Kui Young, Li Kapsok, Seo Seong Jun, Hong Chang Kwun
Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.
Ann Dermatol. 2011 Dec;23(Suppl 3):S306-9. doi: 10.5021/ad.2011.23.S3.S306. Epub 2011 Dec 27.
BellaGen™ is an injectable acellular dermal matrix granule derived from donated human skin tissue that was recently developed for soft tissue augmentation. Its use has been sporadically reported in penile girth enhancement procedures. Many cases of complications have been reported after injecting acellular dermal matrices like AlloDerm or SureDerm™ but few reports on complications associated with BellaGen™ injection. We report here on penile skin inflammation and necrosis following augmentation phalloplasty with BellaGen™, which developed 3 days after the injection and persisted for more than 2 weeks. The patient had a 15 year history of type 2 diabetes mellitus, and he was treated with oral antibiotics and wet dressings with KMNO4 solution to combine preservation of the remaining penile soft tissue with debridement of avascular tissue. The lesion improved with this treatment, but the patient experienced pain for about 2 weeks. All patients should be informed of the potential complications with the use of injectable acellular dermal matrices before treatment. Patient selection for augmentation is also important to have the most desirable results.
BellaGen™是一种可注射的脱细胞真皮基质颗粒，源自捐赠的人类皮肤组织，最近被开发用于软组织填充。其在阴茎增粗手术中的应用已有零星报道。注射AlloDerm或SureDerm™等脱细胞真皮基质后，已有许多并发症的病例报告，但关于BellaGen™注射相关并发症的报道较少。我们在此报告一例使用BellaGen™进行阴茎增粗成形术后阴茎皮肤炎症和坏死的病例，该情况在注射后3天出现，并持续了2周多。患者有15年2型糖尿病病史，接受了口服抗生素治疗以及用高锰酸钾溶液湿敷，以在保留剩余阴茎软组织的同时清除无血管组织。经此治疗，病变有所改善，但患者仍疼痛了约2周。所有患者在治疗前均应被告知使用可注射脱细胞真皮基质的潜在并发症。为获得最理想的效果，增粗手术的患者选择也很重要。
