Micheels P
Dermatol Surg. 2001 Feb;27(2):185-91. doi: 10.1046/j.1524-4725.2001.00248.x.
Although hyaluronan has been acknowledged as being free of species and organ specificity, for 4 years I have encountered a variety of adverse reactions to injectable hyaluronic acid as used in aesthetic medicine.
I have tried to prove that some of those side effects may be allergic reactions to the commercial preparations of injectable hyaluronic acid.
I began with intradermal tests to the reactive patients and to 2 witnesses; then lymphocyte transforming tests were performed at the University of Geneva (Switzerland). Histology was performed on the skin tests and on reactive treated areas of the face of different patients. A serum analysis was then done by Pr. Sainte Laudy of Laboratoire Pasteur--Cerba (France).
The skin tests were positive for one or the other or both of the injectable hyaluronic acid preparations used in aesthetic medicine. The different biopsies have shown for some a chronic inflammatory reaction, even 11 months after the treatment or a severe granulamatous reaction to foreign bodies. Serum analysis revealed positive antibodies against Restylane and/or Hylaform and even IgG and E anti-hyaluronic acid.
Since 1995, I have 8 patients with adverse reactions to injectable hyaluronic acid, which after several tests, may be allergic to those products. Isn't it time to introduce intradermal tests before any injection of this type, as done with injectable bovine collagen?
尽管透明质酸被认为不存在物种和器官特异性，但在过去4年里，我遇到了多种与美容医学中使用的注射用透明质酸相关的不良反应。
我试图证明其中一些副作用可能是对注射用透明质酸商业制剂的过敏反应。
我首先对有反应的患者和2名对照者进行皮内试验；然后在瑞士日内瓦大学进行淋巴细胞转化试验。对不同患者的皮肤试验部位和面部有反应的治疗区域进行组织学检查。随后由法国巴斯德 - 塞尔巴实验室的圣洛迪教授进行血清分析。
对于美容医学中使用的一种或另一种或两种注射用透明质酸制剂，皮肤试验呈阳性。不同的活检显示，有些患者出现慢性炎症反应，甚至在治疗后11个月仍有，或对异物有严重的肉芽肿反应。血清分析显示针对瑞蓝和/或海魅的抗体呈阳性，甚至还有抗透明质酸的IgG和E抗体。
自1995年以来，我有8例患者对注射用透明质酸有不良反应，经过多项测试，可能对这些产品过敏。是否应该像对注射用牛胶原蛋白那样，在进行任何此类注射前引入皮内试验呢？
