Gourdeau M, Deschênes L, Caron M, Desmarais M
Departments of Medicine, Clinical Microbiology, and Pharmacy, Hôpital de l'Enfant-Jésus, Université Laval, Québec.
Can J Infect Dis. 1993 May;4(3):158-62. doi: 10.1155/1993/412737.
An out-patient parenteral antibiotic therapy program provided through a medical day care unit was evaluated in a tertiary care hospital. From July 11, 1988 to December 31, 1990, 122 patients were treated either on site at the unit or at home with self-administered intravenous antibiotics. In all, 142 courses of parenteral antibiotics (mostly cephalosporins and clindamycin) were given for a total of 124 infections, mostly bone and soft tissue infections (67 of 124, 54%). The duration of out-patient therapy ranged from two to 62 days with a mean duration of 9.4 days if treated at the unit, or 13.2 days in the home care model (1476 patient-days). Vein access was peripheral and catheters remained functional for an average of 4.9 days (range 0.5 to 22 days). Only two patients experienced adverse drug reactions that necessitated modification of treatment. One other case was readmitted to the hospital for surgical debridement. The average cost per patient-day was $66 compared with $375 for in-hospital therapy. This program proved to be safe, efficient, and cost-effective.
在一家三级护理医院对通过医疗日间护理单位提供的门诊胃肠外抗生素治疗方案进行了评估。从1988年7月11日至1990年12月31日，122例患者在该单位现场或在家中接受了自行注射的静脉抗生素治疗。总共给予了142个胃肠外抗生素疗程（主要是头孢菌素和克林霉素），共治疗124例感染，主要是骨和软组织感染（124例中的67例，占54%）。门诊治疗时间为2至62天，在单位治疗的平均时间为9.4天，在家护理模式下为13.2天（1476个患者日）。静脉通路为外周静脉，导管平均保持功能4.9天（范围为0.5至22天）。只有两名患者出现药物不良反应，需要调整治疗。另有1例因手术清创再次入院。每位患者每天的平均费用为66美元，而住院治疗为375美元。该方案被证明是安全、有效且具有成本效益的。
