Gentry L O
Baylor College of Medicine, Houston, Texas.
Infect Dis Clin North Am. 1990 Sep;4(3):485-99.
Antibiotic therapy for osteomyelitis has dramatically changed within the past twenty years. The diagnostic criteria for osteomyelitis remain confusing to practicing physicians. Bone biopsy culture is now the standard for determining specific antimicrobial therapy. Many of the newest and most potent antimicrobials are now used to treat the increasingly broad bacterial spectrum of etiologies of osteomyelitis. There are tremendous economic incentives for outpatient and/or oral therapy. The third-generation cephalosporins and the new fluoroquinolones have replaced older, more toxic regimens, especially those containing aminoglycoside used to treat gram-negative osteomyelitis due to susceptible organisms.
在过去二十年中，骨髓炎的抗生素治疗发生了巨大变化。骨髓炎的诊断标准对于执业医师来说仍然令人困惑。骨活检培养现在是确定特定抗菌治疗的标准。许多最新、最有效的抗菌药物现在被用于治疗骨髓炎病因中日益广泛的细菌谱。门诊和/或口服治疗有巨大的经济诱因。第三代头孢菌素和新型氟喹诺酮类药物已经取代了毒性更强的旧治疗方案，尤其是那些含有氨基糖苷类药物用于治疗由易感菌引起的革兰氏阴性骨髓炎的方案。
