Parker P J, Gyorkos T W, Dylewski J S, Joshi A K, Franco E D
McGill University Faculty of Medicine; Department of Epidemiology and Biostatistics, McGill University and Division of Clinical Epidemiology, Montreal General Hospital; Infectious Disease and Microbiology, St Mary's Hospital; Department of Obstetrics and Gynaecology, St Mary's Hospital; and Research Unit, Jewish General Hospital, Department of Family Medicine, McGill University, Montreal, Quebec.
Can J Infect Dis. 1993 Sep;4(5):288-91. doi: 10.1155/1993/986932.
This retrospective study reviewed the screening practice and seroprevalence of hepatitis B surface antigen (HBsAg) among all mothers with live births at a teaching hospital in Montreal between November 1, 1990 and April 30, 1991.
Most women (94%) were screened prenatally and 5.2% postnatally. Screening status could not be determined for 0.8% of women. One-quarter of all postnatal screening results were available only at 48 h or more postdelivery. No infants born to women with postnatal screening or to women with unknown screening status were immunized expectantly. The maternal seroprevalence was 1.08% (95% confidence interval from 0.6, 1.4). All 22 infants born to HBsAg-positive mothers had received hepatitis B immune globulin within 12 h of birth and the first dose of hepatitis B vaccine within 24 h. Follow-up of infants revealed that only 50% had received the second and third doses according to the recommended protocol, with 83% completing the immunization series.
These results indicate that a program of prenatal HBsAg screening and neonatal prophylaxis against hepatitis B can be successfully instituted in a high volume obstetric hospital, and that better monitoring of infants is required to ensure completion of vaccination.
这项回顾性研究回顾了1990年11月1日至1991年4月30日期间在蒙特利尔一家教学医院所有顺产母亲中乙肝表面抗原（HBsAg）的筛查情况和血清流行率。
大多数女性（94%）在产前接受了筛查，5.2%在产后接受了筛查。0.8%的女性筛查状态无法确定。所有产后筛查结果的四分之一仅在分娩后48小时或更长时间才能获得。对于产后接受筛查的女性或筛查状态不明的女性所生的婴儿，均未进行预期免疫接种。母亲的血清流行率为1.08%（95%置信区间为0.6至1.4）。所有22名HBsAg阳性母亲所生的婴儿在出生后12小时内均接受了乙肝免疫球蛋白，并在24小时内接种了第一剂乙肝疫苗。对婴儿的随访显示，只有50%的婴儿按照推荐方案接种了第二剂和第三剂疫苗，83%的婴儿完成了免疫接种系列。
这些结果表明，在一家大型产科医院可以成功实施产前HBsAg筛查和新生儿乙肝预防计划，并且需要更好地监测婴儿以确保完成疫苗接种。
